Evidence map›Paper›PMID 37068958›Full record

ArticleNeurology2023

White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease.

Jianqiao Tian, Sheelakumari Raghavan, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci and 4 more

Abstract read
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In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  15. How fiber bundle alterations differ in presumed LATE and amnestic Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. In vivo effect of LATE-NC on integrity of white matter connections to the hippocampus.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jianqiao TianFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-3994-2922
Sheelakumari RaghavanFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-8652-7011
Robert I ReidFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Scott A PrzybelskiFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Timothy G LesnickFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Robel K GebreFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Jonathan Graff-RadfordFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Christopher G SchwarzFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-1466-8357
Val J LoweFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Kejal KantarciFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
David S KnopmanFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.
Ronald C PetersenFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-8178-6601
Clifford R JackFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-7916-622X
Prashanthi VemuriFrom the Department of Radiology (J.T., S.R., R.K.G., C.G.S., V.J.L., K.K., C.R.J., P.V.), Mayo Clinic; Mayo Clinic Graduate School of Biomedical Sciences (J.T.); and Department of Information Technology (R.I.R.), Department of Quantitative Health Sciences (S.A.P., T.G.L.), and Department of Neurology (J.G.-R., D.S.K., R.C.P.), Mayo Clinic, Rochester, MN. vemuri.prashanthi@mayo.edu.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Investigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseR01AG056366 · NIA · MAYO CLINIC ROCHESTER · PI PRASHANTHI VEMURI · 2017 to 2026
$7.0M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe dynamics of white matter (WM) changes are understudied in Alzheimer disease (AD). Our goal was to study the association between flortaucipir PET and WM health using neurite orientation dispersion and density imaging (NODDI) and evaluate its association with cognitive performance. Specifically, we focused on NODDI's Neurite Density Index (NDI), which aids in capturing axonal degeneration in WM and has greater specificity than single-shell diffusion MRI methods.

methodWe estimated regional flortaucipir PET standard uptake value ratios (SUVRs) from 3 regions corresponding to Braak stage I, III/IV, and V/VI to capture the spatial distribution pattern of the 3R/4R tau in AD. Then, we evaluated the associations between these measurements and NDIs in 29 candidate WM tracts using Pearson correlation and multiple regression models.

resultsBased on 223 participants who were amyloid positive (mean age of 78 years and 57.0% male, 119 cognitively unimpaired, 56 mild cognitive impairment, and 48 dementia), the results showed that WM tracts NDI decreased with increasing regional Braak tau SUVRs. Of all the significant WM tracts, the uncinate fasciculus ( DISCUSSION: We found spatially dependent WM degeneration associated with regional flortaucipir SUVRs in Braak stages, suggesting a spatial pattern in WM damage. NDI, a specific marker of axonal density, provides complementary information about disease staging and progression in addition to tau deposition. Measurements of WM changes are important for the mechanistic understanding of multifactorial pathways through which AD causes cognitive dysfunction.

Indexed as

Alzheimer DiseaseCognitive DysfunctionWhite MatterAgedAmyloidogenic ProteinsAxonsCarbolinesCell MembraneFemaleHumansMalePositron-Emission Tomographytau ProteinsAmyloidogenic ProteinsCarbolinestau Proteins

Identifiers

PMID37068958
PMCPMC10259272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.