Observational studyNeurology2023
Functional Connectivity From Disease Epicenters in Frontotemporal Dementia.
Open access · hybridAbstract readObservational Study
In one paragraph
Observational study in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia.CNS neuroscience & therapeutics · 2024Trial
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Parallel multilink group joint ICA (pmg-jICA): Fusion of 3D structural and 4D functional data across multiple resting fMRI networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Neuroimaging epicenters and the related neurobiological signatures in patients with postherpetic neuralgia.The journal of headache and pain · 2025Article
- Anterior Insula Drives Progressive Structural Brain Network Atrophy in the Behavioural Variant of Frontotemporal Dementia.Human brain mapping · 2025Article
- Social exposome and brain health outcomes of dementia across Latin America.Nature communications · 2025Article
- Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants.European journal of neurology · 2025Article
- Longitudinal evaluation of common and unique brain-networks in variants of primary progressive aphasia.Alzheimer's research & therapy · 2025Article
- Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Modelling pathological spread through the structural connectome in the frontotemporal dementia clinical spectrum.Brain : a journal of neurology · 2025Article
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- Frontotemporal dementia characterization using neurite orientation dispersion and density imaging.Brain communications · 2025Article
- Clinical Manifestations and Neural Basis of Semantic Dementia: Converging Evidences From Brain Imaging Studies.Clinical interventions in aging · 2025Review
- Stepwise Functional Brain Architecture Correlates with Atrophy in Progressive Supranuclear Palsy.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy.Cognitive neurodynamics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 2 institutions in 2 countries.
Federica AgostaFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy. agosta.federica@hsr.it.ORCID 0000-0003-3121-4979
Edoardo Gioele SpinelliFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-1492-7221
Silvia BasaiaFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Camilla CividiniFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesco FalboFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Costanza PavoneFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nilo RivaFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-0513-9517
Elisa CanuFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Veronica CastelnovoFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giuseppe MagnaniFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesca CasoFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola CaroppoFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Sara PrioniFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-9632-0591
Cristina VillaFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-2125-2886
Lucio TremolizzoFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ildebrando AppollonioFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vincenzo SilaniFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Keith A JosephsFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jennifer WhitwellFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.
Massimo FilippiFrom the Neuroimaging Research Unit (F.A., E.G.S., S.B., C.C., F.F., C.P., E.C., V.C., M.F.), Division of Neuroscience, and Neurology Unit (F.A., E.G.S., G.M., F.C., M.F.), IRCCS San Raffaele Scientific Institute; Vita-Salute San Raffaele University (F.A., F.F., C.P., M.F.); Neurorehabilitation Unit (N.R., M.F.), IRCCS San Raffaele Scientific Institute; Experimental Neuropathology Unit (N.R.), Division of Neuroscience, IRCCS San Raffaele Scientific Institute; Unit of Neurology 5-Neuropathology (P.C., S.P., C.V.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; Neurology Unit (L.T., I.A.), "San Gerardo" Hospital and University of Milano-Bicocca, Monza; Department of Neurology and Laboratory of Neuroscience (V.S.), IRCCS Istituto Auxologico Italiano, Milan; "Dino Ferrari" Center (V.S.), Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Italy; Department of Neurology (K.A.J.), and Department of Radiology (J.W.), Mayo Clinic, Rochester, MN; and Neurophysiology Service (M.F.), IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0002-5485-0479
Vita-Salute San Raffaele University · ITMayo Clinic · US
Funding
Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2MThe neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9MPIB PET Scanning in Speech and Language Based DementiasR01DC010367 · NIDCD · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2014
$1.7MAssessment of hyperphosphorylated tau PET binding in primary progressive aphasiaR21NS094684 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2016 to 2017
$417kNIDCD NIH HHS R01 DC010367NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942NINDS NIH HHS R21 NS094684
Abstract
BACKGROUND AND
objectivesMRI connectomics is an ideal tool to test a network-based model of pathologic propagation from a disease epicenter in neurodegenerative disorders. In this study, we used a novel graph theory-based MRI paradigm to explore functional connectivity reorganization, discerning between direct and indirect connections from disease epicenters, and its relationship with neurodegeneration across clinical presentations of the frontotemporal dementia (FTD) spectrum, including behavioral variant of FTD (bvFTD), nonfluent variant of primary progressive aphasia (nfvPPA), and semantic variant of primary progressive aphasia (svPPA).
methodsIn this observational cross-sectional study, disease epicenters were defined as the peaks of atrophy of a cohort of patients with high confidence of frontotemporal lobar degeneration pathology (Mayo Clinic). These were used as seed regions for stepwise functional connectivity (SFC) analyses in an independent (Milan) set of patients with FTD to assess connectivity in regions directly and indirectly connected to the epicenters. Correlations between SFC architecture in healthy conditions and atrophy patterns in patients with FTD were also tested.
resultsAs defined by comparing the 42 Mayo Clinic patients with 15 controls, disease epicenters were the left anterior insula for bvFTD, left supplementary motor area for nfvPPA, and left inferior temporal gyrus (ITG) for svPPA. Compared with 94 age-matched controls, patients with bvFTD (n = 64) and nfvPPA (n = 34) of the Milan cohort showed widespread decreased SFC in bilateral cortical regions with direct/indirect connections with epicenters and increased SFC either in directly connected regions, physically close to the respective seed region, or in more distant cortical/cerebellar areas with indirect connections. Across all link steps, svPPA (n = 36) showed SFC decrease mostly within the temporal lobes, with co-occurrent SFC increase in cerebellar regions at indirect link steps. The average stepwise topological distance from the left ITG in a reference group of 50 young healthy controls correlated with regional gray matter volume in svPPA, consistent with network-based degeneration. DISCUSSION: Our findings demonstrate that each FTD syndrome is associated with a characteristic interplay of decreased and increased functional connectivity with the disease epicenter, affecting both direct and indirect connections. SFC revealed novel insights regarding the topology of functional disconnection across FTD syndromes, holding the promise to be used to model disease progression in future longitudinal studies.
Indexed as
Aphasia, Primary ProgressiveFrontotemporal DementiaPick Disease of the BrainPrimary Progressive Nonfluent AphasiaAtrophyHumansMagnetic Resonance Imaging
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.