Evidence map›Paper›PMID 37068770›Full record

ReviewAnnual review of biochemistry2023

The Proteins of mRNA Modification: Writers, Readers, and Erasers.

Mathieu N Flamand, Matthew Tegowski, Kate D Meyer

Abstract readReview
In one paragraph

Review in Annual review of biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. NAR cancer · 2026
    Article
  3. Review
  4. Article
  5. Mechanistic Insights Into the Oxidative Reactivity of 2-Selenouridine in tRNA.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Emerging roles of mJournal of assisted reproduction and genetics · 2026
    Review
  10. Article
  11. Article
  12. mArXiv · 2026
    Article
  13. Review
  14. Article
  15. METTL14-dependent mbioRxiv : the preprint server for biology · 2026
    Article
  16. The bladder cancer mEMBO reports · 2026
    Article
  17. Review
  18. Review
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mathieu N FlamandDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA; email: kate.meyer@duke.edu.
Matthew TegowskiDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA; email: kate.meyer@duke.edu.
Kate D MeyerDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA; email: kate.meyer@duke.edu.

Funding

Epitranscriptomic Regulation of Synaptic Responses to Drugs of AbuseDP1DA046584 · NIDA · DUKE UNIVERSITY · PI MEYER, KATHRYN D · 2018 to 2022
$2.4M
Mechanistic Insights into m6A-Mediated Regulation of Brain DevelopmentR01MH118366 · NIMH · DUKE UNIVERSITY · PI MEYER, KATHRYN D · 2019 to 2023
$2.0M
mRNA Methylation: a Novel Regulatory Mechanism in the Neuronal TranscriptomeR00MH104712 · NIMH · DUKE UNIVERSITY · PI MEYER, KATHRYN D · 2016 to 2018
$747k
NIDA NIH HHS DP1 DA046584NIMH NIH HHS R00 MH104712NIMH NIH HHS R01 MH118366
6 · The paper itself

Abstract

Over the past decade, mRNA modifications have emerged as important regulators of gene expression control in cells. Fueled in large part by the development of tools for detecting RNA modifications transcriptome wide, researchers have uncovered a diverse epitranscriptome that serves as an additional layer of gene regulation beyond simple RNA sequence. Here, we review the proteins that write, read, and erase these marks, with a particular focus on the most abundant internal modification,

Indexed as

AdenosineGene Expression RegulationProteinsRNA, MessengerTranscriptomeAdenosineProteinsRNA, Messengerdemethylaseepitranscriptomem6Amethyltransferasereader proteinRNA modifications

Identifiers

PMID37068770
PMCPMC10443600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.