Evidence map›Paper›PMID 37068623›Full record

ArticleAnnals of vascular surgery2023

Thoracic Endovascular Aortic RepairAcutely Augments Left Ventricular Biomechanics in An Animal Model: A Mechanism for Postoperative Heart Failure and Hypertension.

David P Stonko, Joseph Edwards, Hossam Abdou, Rebecca N Treffalls, Patrick Walker, Randall R DeMartino, Bernardo C Mendes, Caitlin W Hicks, Jonathan J Morrison

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of vascular surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

David P StonkoDepartment of Surgery, The Johns Hopkins Hospital, Baltimore, MD; R. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD.
Joseph EdwardsR. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD.
Hossam AbdouR. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD.
Rebecca N TreffallsR. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD.
Patrick WalkerR. Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD.
Randall R DeMartinoDivison of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN.
Bernardo C MendesDivison of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN.
Caitlin W HicksDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD.
Jonathan J MorrisonDivison of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN. Electronic address: morrison.jonathan@mayo.edu.
University of Maryland, Baltimore · USMayo Clinic · USJohns Hopkins Hospital · US

Funding

Risk Factors and Outcomes Associated with Late-Life Diabetic Peripheral NeuropathyK23DK124515 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HICKS, CAITLIN WHITNEY · 2020 to 2024
$898k
NIDDK NIH HHS K23 DK124515
6 · The paper itself

Abstract

backgroundThoracic aortic stent grafts are thought to decrease aortic compliance and may contribute to hypertension and heart failure after thoracic endovascular aortic repair (TEVAR). Left ventricular (LV) biomechanics immediately after TEVAR, however, have not been quantified. Pressure-volume (PV) loop analysis provides gold-standard LV functional information. The aim of this study is to use an LV PV loop catheter and analysis to characterize the LV biomechanics before and acutely after TEVAR.

methodsAnesthetized Yorkshire swine (N = 6) were percutaneously instrumented with an LV PV loop catheter. A 20 mm × 10 cm stent graft was deployed distal to the left subclavian via the femoral artery under fluoroscopy. Cardiac biomechanics were assessed before and after TEVAR. As a sensitivity analysis, inferior vena cava occlusion with PV loop assessment was performed pre and post-TEVAR in 1 animal to obtain preload and afterload-independent end-systolic and end-diastolic PV relationships (ESPVR and EDPVR).

resultsAll animals underwent successful instrumentation and TEVAR. Post-TEVAR, all 6 animals had higher mean LV ESP (106 vs. 118 mm Hg, P = 0.04), with no change in the EDPVR. inferior vena cava occlusion also moved the ESPVR curve upward and leftward, indicating increased LV work per unit time. There was no augmentation of EDPVR following TEVAR (P > 0.05). Postmortem exams in all animals revealed appropriate stent placement and no technical complications.

conclusionsTEVAR was associated with an acute increase in LV end-systolic pressure and shift in the ESPVR, indicating increased ventricular work. This data provides potential mechanistic insights into the development of post-TEVAR hypertension and heart failure. Future stent graft innovation should focus on minimizing the changes in cardiac physiology.

Indexed as

Aortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationEndovascular ProceduresHeart FailureHypertensionAnimalsAorta, ThoracicBiomechanical PhenomenaBlood Vessel ProsthesisRetrospective StudiesStentsSwineTreatment Outcome

Identifiers

PMID37068623
PMCPMC10754260
OpenAlexW4365815152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.