Evidence map›Paper›PMID 37068329›Full record

ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023

Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee.

Steve Vucic, Kai-Hsiang Stanley Chen, Matthew C Kiernan, Mark Hallett, David H Benninger, Vincenzo Di Lazzaro, Paolo M Rossini, Alberto Benussi, Alfredo Berardelli, Antonio Currà and 12 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 12 pooled it
23.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 12 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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  7. Systematic review and meta-analysis of repetitive transcranial magnetic stimulation (rTMS) for activities of daily living in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  20. Corticospinal conduction in RFC1-related disease: a transcranial magnetic stimulation study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 11 countries.

Steve VucicBrain, Nerve Research Center, The University of Sydney, Sydney, Australia. Electronic address: steve.vucic@sydney.edu.au.
Kai-Hsiang Stanley ChenDepartment of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan.
Matthew C KiernanBrain and Mind Centre, The University of Sydney; and Department of Neurology, Royal Prince Alfred Hospital, Australia.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, Maryland, United States.
David H BenningerDepartment of Neurology, University Hospital of Lausanne (CHUV), Switzerland.
Vincenzo Di LazzaroUnit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, Rome, Italy.
Paolo M RossiniDepartment of Neurosci & Neurorehab IRCCS San Raffaele-Rome, Italy.
Alberto BenussiCentre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alfredo BerardelliIRCCS Neuromed, Pozzilli; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Antonio CurràDepartment of Medico-Surgical Sciences and Biotechnologies, Alfredo Fiorini Hospital, Sapienza University of Rome, Terracina, LT, Italy.
Sandro M KriegDepartment of Neurosurgery, Technical University Munich, School of Medicine, Klinikum rechts der Isar, Munich, Germany.
Jean-Pascal LefaucheurUniv Paris Est Creteil, EA4391, ENT, Créteil, France; Clinical Neurophysiology Unit, Henri Mondor Hospital, AP-HP, Créteil, France.
Yew Long LoDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, and Duke-NUS Medical School, Singapore.
Richard A MacdonellDepartment of Neurology, Austin Health, Heidelberg VIC, Australia.
Marcello MassiminiDipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy; Istituto Di Ricovero e Cura a Carattere Scientifico, Fondazione Don Carlo Gnocchi, Milan, Italy.
Mario RosanovaDepartment of Biomedical and Clinical Sciences University of Milan, Milan, Italy.
Thomas PichtDepartment of Neurosurgery, Charité-Universitätsmedizin Berlin, Cluster of Excellence: "Matters of Activity. Image Space Material," Humboldt University, Berlin Simulation and Training Center (BeST), Charité-Universitätsmedizin Berlin, Germany.
Cathy M StinearDepartment of Medicine Waipapa Taumata Rau, University of Auckland, Auckland, Aotearoa, New Zealand.
Walter PaulusDepartment of Neurology, Ludwig-Maximilians-Universität München, München, Germany.
Yoshikazu UgawaDepartment of Human Neurophysiology, School of Medicine, Fukushima Medical University, Japan.
Ulf ZiemannDepartment of Neurology and Stroke, Eberhard Karls University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany; Hertie Institute for Clinical Brain Research, Eberhard Karls University of Tübingen, Otfried-Müller-Straße 27, 72076 Tübingen, Germany.
Robert ChenEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital-UHN, Division of Neurology-University of Toronto, Toronto Canada.
The University of Sydney · AUUniversity of Milan · ITAustin Health · AUCluster of Excellence "Matters of Activity. Image Space Material" · DEFukushima Medical University · JPHertie Institute for Clinical Brain Research · DEIstituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Neurologico Mediterraneo · ITLudwig-Maximilians-Universität München · DENational Institutes of Health · USNational Taiwan University Hospital · TWSapienza University of Rome · ITSingapore General Hospital · SGToronto Western Hospital · CATUM Klinikum · DEUniversità Campus Bio-Medico · ITUniversité Paris-Est Créteil · FRUniversity Hospital of Lausanne · CHUniversity of Auckland · NZUniversity of Brescia · IT

Funding

Pathophysiology of Involuntary Movements and Volitional DisordersZIANS002667 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$17.7M
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

The review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. Most TMS measures rely on stimulation of motor cortex and recording of motor evoked potentials. Paired-pulse TMS techniques, incorporating conventional amplitude-based and threshold tracking, have established clinical utility in neurodegenerative, movement, episodic (epilepsy, migraines), chronic pain and functional diseases. Cortical hyperexcitability has emerged as a diagnostic aid in amyotrophic lateral sclerosis. Single-pulse TMS measures are of utility in stroke, and myelopathy even in the absence of radiological changes. Short-latency afferent inhibition, related to central cholinergic transmission, is reduced in Alzheimer's disease. The triple stimulation technique (TST) may enhance diagnostic utility of conventional TMS measures to detect upper motor neuron involvement. The recording of motor evoked potentials can be used to perform functional mapping of the motor cortex or in preoperative assessment of eloquent brain regions before surgical resection of brain tumors. TMS exhibits utility in assessing lumbosacral/cervical nerve root function, especially in demyelinating neuropathies, and may be of utility in localizing the site of facial nerve palsies. TMS measures also have high sensitivity in detecting subclinical corticospinal lesions in multiple sclerosis. Abnormalities in central motor conduction time or TST correlate with motor impairment and disability in MS. Cerebellar stimulation may detect lesions in the cerebellum or cerebello-dentato-thalamo-motor cortical pathways. Combining TMS with electroencephalography, provides a novel method to measure parameters altered in neurological disorders, including cortical excitability, effective connectivity, and response complexity.

Indexed as

Alzheimer DiseaseAmyotrophic Lateral SclerosisNervous System DiseasesEvoked Potentials, MotorHumansTranscranial Magnetic StimulationMotor evoked potentialNeurological disordersShort interval intracortical inhibitionTranscranial magnetic stimulation

Identifiers

PMID37068329
PMCPMC10192339
OpenAlexW4361306774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.