Evidence map›Paper›PMID 37067791›Full record

ArticleThe Journal of experimental medicine2023

Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain.

Florian Mayrhofer, Angela M Hanson, Manuel F Navedo, Yang K Xiang, Athena M Soulika, Wenbin Deng, Olga V Chechneva

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Florian MayrhoferInstitute for Pediatric Regenerative Medicine, Shriners Children's Northern California , Sacramento, CA, USA.ORCID 0009-0008-3779-6184
Angela M HansonInstitute for Pediatric Regenerative Medicine, Shriners Children's Northern California , Sacramento, CA, USA.ORCID 0009-0000-4450-1163
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.ORCID 0000-0001-6864-6594
Yang K XiangDepartment of Pharmacology, University of California, Davis, Davis, CA, USA.ORCID 0000-0003-1786-9143
Athena M SoulikaInstitute for Pediatric Regenerative Medicine, Shriners Children's Northern California , Sacramento, CA, USA.ORCID 0000-0001-6746-3876
Wenbin DengInstitute for Pediatric Regenerative Medicine, Shriners Children's Northern California , Sacramento, CA, USA.ORCID 0000-0002-8897-4891
Olga V ChechnevaInstitute for Pediatric Regenerative Medicine, Shriners Children's Northern California , Sacramento, CA, USA.ORCID 0000-0002-8057-5669
Shriners Hospitals for Children - Northern California · USSun Yat-sen University · CNUniversity of California, Davis · USVA Northern California Health Care System · US

Funding

Cerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7M
Differentiation and Integration of Trisomy 21 iPSCs in an Animal ModelR01HD091325 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2017 to 2021
$1.6M
Novel mechanism on subpopulation-dependent biased GPCR signaling in neuronsR01GM129376 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2018 to 2021
$1.6M
Regenerating CNS white matter using induced pluripotent stem cellsR01HD087566 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENG, WENBIN · 2016 to 2020
$1.5M
NHLBI NIH HHS R01 HL149127NICHD NIH HHS R01 HD087566NICHD NIH HHS R01 HD091325NIGMS NIH HHS R01 GM129376
6 · The paper itself

Abstract

Material transfer is an essential form of intercellular communication to exchange information and resources between cells. Material transfer between neurons and from glia to neurons has been demonstrated to support neuronal survival and activity. Understanding the extent of material transfer in the healthy nervous system is limited. Here we report that in the mouse central nervous system (CNS), neurons receive nuclear and ribosomal material of Sox10-lineage cell (SOL) origin. We show that transfer of SOL-derived material to neurons is region dependent, establishes during postnatal brain maturation, and dynamically responds to LPS-induced neuroinflammation in the adult mouse brain. We identified satellite oligodendrocyte-neuron pairs with loss of plasma membrane integrity between nuclei, suggesting direct material transfer. Together, our findings provide evidence of regionally coordinated transfer of SOL-derived nuclear and ribosomal material to neurons in the mouse CNS, with potential implications for the understanding and modulation of neuronal function and treatment of neurological disorders.

Indexed as

NeurogliaNeuronsAnimalsBrainMiceOligodendrogliaSOXE Transcription FactorsSox10 protein, mouseSOXE Transcription Factors

Identifiers

PMID37067791
PMCPMC10114922
OpenAlexW4366083239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.