Evidence map›Paper›PMID 37067664›Full record

ArticleMycopathologia2023

Aspergillus Species Causing Invasive Fungal Disease in Queensland, Australia.

Adam G Stewart, Burcu Isler, Peter Simos, Drew Farquhar, Narelle George, Mila Golmayo, Claire Heney

Open access · hybridAbstract read
In one paragraph

Article in Mycopathologia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. BeyondAntimicrobial agents and chemotherapy · 2026
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  6. Prevalence of Azole-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Adam G StewartCentre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Australia. Adam.Stewart@health.qld.gov.au.
Burcu IslerCentre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane and Women's Hospital Campus, Brisbane, Australia.
Peter SimosInfection Management Services, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Drew FarquharDepartment of Infectious Diseases, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Narelle GeorgeCentral Microbiology, Pathology Queensland, Brisbane, Australia.
Mila GolmayoCentral Microbiology, Pathology Queensland, Brisbane, Australia.
Claire HeneyCentral Microbiology, Pathology Queensland, Brisbane, Australia.
The University of Queensland · AUPrincess Alexandra Hospital · AURoyal Brisbane and Women's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAspergillus species are important causes of invasive fungal disease, particularly among those with an impaired immune system. Increasing reports have revealed a rising incidence of antifungal drug resistance among Aspergillus spp., particularly among cryptic species. Understanding local antifungal susceptibility patterns is paramount to delivering optimal clinical care.

methodsAspergillus spp. recovered from clinical specimens between 2000 and 2021 from Pathology Queensland were collected. Aspergillus spp. were identified routinely morphologically, and where there was ambiguity or a lack of sporulation, by sequencing of the internal transcribed spacer (ITS) region. All Aspergillus spp. that underwent antifungal susceptibility testing according to the CLSI M38-A3 method and were recorded and included in the study. Amphotericin B, voriconazole, posaconazole, isavuconazole, micafungin, caspofungin, and anidulafungin were tested. Pathology Queensland services all public healthcare facilities in Queensland, Australia.

results236 Aspergillus spp. were identified from clinical specimens during the study period. The most frequent species identified were Aspergillus section Fumigati (n = 119), Aspergillus section Flavi (n = 35), Aspergillus terreus (n = 32) and Aspergillus niger (n = 29). Overall, MIC

conclusionIncreasing reports of antifungal resistance among Aspergillus spp. is concerning and warrants further investigation both locally and worldwide. Active surveillance of both the emergence of different Aspergillus spp. and changes in antifungal susceptibility patterns over time is crucial to informing clinicians and treatment guidelines.

Indexed as

Antifungal AgentsMycosesAnidulafunginAspergillusDrug Resistance, FungalHumansMicafunginMicrobial Sensitivity TestsNitrilesPyridinesQueenslandTriazolesVoriconazoleAnidulafunginAntifungal AgentsisavuconazoleMicafunginNitrilesPyridinesTriazolesVoriconazoleAntifungal susceptibility testingAspergillus speciesAzole resistance

Identifiers

PMID37067664
PMCPMC10307696
OpenAlexW4366083063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.