ArticleVeterinary medicine and science2023
Effect of dietary dexamethasone on the morphologic and morphometric adaptations in the lymphoid organs and mortality rate in broilers.
Article in Veterinary medicine and science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Dietary α-Mangostin alleviates lipopolysaccharide-induced stress and enhances growth performance in broilers via improved intestinal immunity and integrity.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Assessment of Coagulansin-A's therapeutic potential and safety in an ovalbumin (OVA) induced airway inflammation model.Inflammopharmacology · 2026Article
- iTRAQ-Based Proteomics Reveals the Potential Mechanisms Underlying Diet Supplementation with Stevia Isochlorogenic Acid That Alleviates Immunosuppression in Cyclophosphamide-Treated Broilers.Animals : an open access journal from MDPI · 2025Article
- A probiotic Brevibacillus laterosporus promotes chicken growth performance immunity and gut health.Scientific reports · 2025Article
- Corticosterone reprograms splenic responses to avian pathogenic Escherichia coli infection in broiler chickens.Poultry science · 2025Article
- RNA-seq analysis of chlorogenic acid intervention in duck embryo fibroblasts infected with duck plague virus.Virology journal · 2024Article
- Effect of dietary dexamethasone on the morphologic and morphometric adaptations in the lymphoid organs and mortality rate in broilers.Veterinary medicine and science · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThymus, bursa of Fabricius and spleen are the major lymphoid organs of avian species that plays a crucial role in their immunity. Though glucocorticoids are reportedly used as growth promoters, they also suppress the immune system.
objectivesThe objective of this study was to investigate the morphologic and morphometric adaptations in the lymphoid organs as well as the mortality rate in broilers in response to long-term treatment with dexamethasone (DEX).
methodsA total of 80 one-day-old broiler chicks (Cobb 500) were randomly divided into four homogenous groups (control - C and treatment groups - T1, T2, and T3). The treatment groups received DEX at the rate of 3, 5, and 7 mg/kg commercial feed. Samples, i.e. thymus, bursa of Fabricius, and spleen, were collected on 7, 14, 21, and 28 days of the experiment. Relative weight of the organs was calculated on each sampling day. The tissues were then processed and stained with haematoxylin and eosin stain for morphological and morphometric study.
resultsThe relative weight of lymphoid organs was found substantially (p < 0.05) less in the DEX-treated groups. Significant (p < 0.05) reduction in lobular size and the cortical-medullary ratio was observed in the thymus of the DEX-treated broilers. Follicular atrophy and massive depletion of lymphocytes were evident in the bursa of Fabricius. The mortality rate was also increased which was largely dependent on the dose and duration of DEX treatment.
conclusionsThe study results indicate that DEX treatment can alter the morphology and morphometry of lymphoid organs which might result in severe immunosuppression and increased mortality rate in broilers.
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