ArticleInterdisciplinary cardiovascular and thoracic surgery2023
Association between vasoactive-inotropic score, morbidity and mortality after heart transplantation.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Standardized Treatment and Diagnostic Approach to Reduce Disease burden in the early postoperative phase in children with congenital heart defects-STANDARD study: a pilot randomized controlled trial.European journal of pediatrics · 2023Trial
- Cold ischemic time and early vasoactive-inotropic support following heart transplantation with HTK-preserved donor hearts.JHLT open · 2026Article
- Vaso-active inotropic scores: Clinical value, pros and cons.JHLT open · 2026Article
- A Comparison of postoperative hemodynamic trajectories in donation after brain death versus circulatory death heart transplantation.JHLT open · 2026Article
- Beating heart technique for orthotopic heart transplantation after ex vivo heart perfusion: Clinical application and experience.JTCVS techniques · 2026Article
- A Novel Approach to Assessing In-Hospital Mortality After On-Pump Aortic Valve Replacement.Life (Basel, Switzerland) · 2025Article
- Predictive factors for death and long-term outcomes in elderly critically ill patients following tracheotomy: a retrospective analysis.BMC anesthesiology · 2025Article
- Vasoactive Inotrope Score as a Predictor of Postoperative Complications in Cancer Surgery Patients-A Prospective Observational Study.Indian journal of surgical oncology · 2024Article
- A retrospective observational study evaluating the association between vasoactive-inotropic score and mortality after major abdominal surgery.Scientific reports · 2024Observational
- Vasoactive-Inotropic Scoring in Cardiac Surgery: Both Concept and Context Matter!Annals of cardiac anaesthesia · 2024Article
- A letter to the editor in response to "Association between vasoactive-inotropic score, morbidity and mortality after heart transplantation".Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Response to Letter to the Editor: A closer look at fast-tracking research in pediatric cardiac surgery.Turk gogus kalp damar cerrahisi dergisi · 2023Article
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9 authors.
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Abstract
objectivesThe aim of this study was to evaluate the association between vasoactive-inotropic score (VIS), calculated in the 24 h after heart transplantation, and post-transplant mortality and morbidity.
methodsThis was an observational single-centre retrospective study. Patients admitted to surgical intensive care unit after transplantation, between January 2015 and December 2018, were reviewed consecutively. VISmax was calculated as dopamine+ dobutamine+ 100 × epinephrine + 100 × norepinephrine + 50 × levosimendan + 10 × milrinone (all in µg/kg/min) + 10 000 × vasopressin (units/kg/min), using the maximum dosing rates of vasoactive and inotropic medications in the 24 h after intensive care unit admission. The primary outcome was mortality at 1 year post-transplant. The secondary outcomes included length of stay, duration of mechanical ventilation and inotropic support and the occurrence of septic shock, ventilator-associated pneumonia, bloodstream infection or renal replacement therapy.
resultsA total of 151 patients underwent heart transplantation and admitted to intensive care unit. The median VISmax was 39.2 (interquartile range = 19.4-83.0). VISmax was independently associated with 1-year post-transplant mortality, as well as recipient age [hazard ratio (HR) = 1.004, P-value = 0.013], recipient gender (female to male: hazard ratio = 2.23, P-value = 0.047) and combined transplantation (hazard ratio = 2.85, P-value = 0.048). There was a significant association between VISmax and duration of mechanical ventilation (P-value < 0.001), length of stay (P-value = 0.002), duration of infused inotropes (P-value < 0.001), occurrence of bloodstream infections, septic shocks, ventilation-acquired pneumonia and renal replacement therapy.
conclusionsVISmax calculated during the first 24 h after postoperative intensive care unit admission in transplanted patients is independently associated with 1-year mortality. In addition, length of stay, duration of mechanical ventilation and infused inotropes increased with increasing VISmax.
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