Evidence map›Paper›PMID 37067465›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Kinetic Resolution of 2-Aryldihydroquinolines Using Lithiation - Synthesis of Chiral 1,2- and 1,4-Dihydroquinolines.

Song-Hee Yeo, Anthony Choi, Sophie Greaves, Anthony J H M Meijer, Ilaria Proietti Silvestri, Iain Coldham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Enantioselective Synthesis of Sealutomicin C.Journal of the American Chemical Society · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Song-Hee YeoDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Anthony ChoiDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Sophie GreavesDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Anthony J H M MeijerDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Ilaria Proietti SilvestriLiverpool ChiroChem, The Heath Business & Technical Park, Runcorn, Cheshire, WA7 4QX, UK.
Iain ColdhamDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.ORCID http://orcid.org/0000-0003-4602-6292

Funding

Engineering and Physical Sciences Research Council EP/R024294/1Royal Society SIF\R2\202031
6 · The paper itself

Abstract

Highly enantiomerically enriched dihydrohydroquinolines were prepared in two steps from quinoline. Addition of aryllithiums to quinoline with tert-butoxycarbonyl (Boc) protection gave N-Boc-2-aryl-1,2-dihydroquinolines. These were treated with n-butyllithium and electrophilic trapping occurred exclusively at C-4 of the dihydroquinoline, a result supported by DFT studies. Variable temperature NMR spectroscopy gave kinetic data for the barrier to rotation of the carbonyl group (ΔG

Indexed as

dihydroquinolinesenantioselectivitykinetic resolutionlithiationnitrogen heterocycles

Identifiers

PMID37067465
PMCPMC10946909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.