Evidence map›Paper›PMID 37067430›Full record

ArticleMicrobiology spectrum2023

Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins.

Camilla Valente Pires, Jenna Oberstaller, Chengqi Wang, Debora Casandra, Min Zhang, Jyotsna Chawla, Swamy Rakesh Adapa, Thomas D Otto, Michael T Ferdig, Julian C Rayner and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Ubiquitin-proteasome system inFrontiers in medicine · 2024
    Pooled it
  2. mSphere · 2026
    Article
  3. Profiling 26S Proteasome Activity ofInternational journal of molecular sciences · 2026
    Article
  4. Article
  5. Single-cell transcriptional changes of artemisinin-sensitive K13Frontiers in cellular and infection microbiology · 2026
    Article
  6. Article
  7. The essential genome ofScience (New York, N.Y.) · 2025
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Camilla Valente PiresCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.ORCID 0000-0002-5470-1342
Jenna OberstallerCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Chengqi WangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Debora CasandraCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Min ZhangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Jyotsna ChawlaCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Swamy Rakesh AdapaCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
Thomas D OttoInstitute of Infection, Immunity and Inflammation, MVLS, University of Glasgow, Glasgow, United Kingdom.
Michael T FerdigEck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Julian C RaynerCambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.
Rays H Y JiangCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.
John H AdamsCenter for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA.ORCID 0000-0003-3707-7979
University of South Florida · USUniversity of Cambridge · GBUniversity of Glasgow · GBUniversity of Notre Dame · US

Funding

Chemogenomic Profiling of Plasmodium Falciparum Responses and ResistanceR01AI117017 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI ADAMS, JOHN H · 2015 to 2025
$6.9M
Discovering the essential genome of Plasmodium falciparumR01AI130171 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI ADAMS, JOHN H · 2018 to 2021
$2.8M
NIAID NIH HHS R01 AI117017NIAID NIH HHS R01 AI130171
6 · The paper itself

Abstract

The antimalarial activity of the frontline drug artemisinin involves generation of reactive oxygen species (ROS) leading to oxidative damage of parasite proteins. To achieve homeostasis and maintain protein quality control in the overwhelmed parasite, the ubiquitin-proteasome system kicks in. Even though molecular markers for artemisinin resistance like

Indexed as

AntimalarialsArtemisininsMalariaMalaria, FalciparumBortezomibDrug ResistanceHumansLipid MetabolismPlasmodium falciparumProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan ProteinsUbiquitinAntimalarialsartemisininArtemisininsartenimolBortezomibProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan ProteinsUbiquitinchemogenomicsdrug profilesmalariaPlasmodium falciparum

Identifiers

PMID37067430
PMCPMC10269874
OpenAlexW4366082847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.