ArticleApplied and environmental microbiology2023
Serratia marcescens Colonization in a Neonatal Intensive Care Unit Has Multiple Sources, with Sink Drains as a Major Reservoir.
Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- A standardized workflow for typing S. marcescens outbreaks using FT-IR spectroscopy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Antimicrobial Resistance of Serratia marcescens Recovered From Aquatic Environments: A Review.Environmental microbiology reports · 2026Review
- Identifying and quantifying ESKAPEE pathogens in and around sinks in high burden hospitals.The Journal of hospital infection · 2026Observational
- Review
- From Environmental Organism to Nosocomial Threat:Antibiotics (Basel, Switzerland) · 2026Review
- Ecological dynamics of three persistent opportunistic pathogens in hospital sinks and their potential antagonistic bacteria.mSystems · 2026Article
- Identifying and quantifying ESKAPEE pathogens in and around sinks in high burden hospitals.medRxiv : the preprint server for health sciences · 2026Article
- Aerosol-based exposure to opportunistic pathogens originating from hospital sink drains.American journal of infection control · 2026Article
- Evaluation of Fourier transform infrared spectroscopy as a first-line surveillance typing tool forFrontiers in antibiotics · 2026Article
- Review
- Molecular Epidemiology of Clinical Infections Caused by Serratia marcescens Complex in a Tertiary Care Hospital System: Insights From Whole-Genome Sequencing.The Journal of infectious diseases · 2025Article
- The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens.npj antimicrobials and resistance · 2025Review
- Plasmid diversity ofMicrobiology spectrum · 2025Article
- Rapid identification of a Serratia marcescens outbreak in a neonatal intensive care unit by third-generation long-read nanopore sequencing.Antimicrobial resistance and infection control · 2025Article
- Global genomic epidemiology and plasmid-mediated dissemination ofCurrent research in microbial sciences · 2025Article
- Whole-genome sequencing-based source tracing and infection control ofFrontiers in microbiology · 2025Article
- The drainome: longitudinal metagenomic characterization of wastewater from hospital ward sinks to characterize the microbiome and resistome and to assess the effects of decontamination interventions.The Journal of hospital infection · 2024Article
- Nosocomial outbreak caused by disinfectant-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Article
- Cultivation and sequencing-free protocol foriScience · 2024Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Compelling evidence suggests a contribution of the sink environment to the transmission of opportunistic pathogens from the hospital environment to patients in neonatal intensive care units (NICU). In this study, the distribution of the opportunistic pathogen Serratia marcescens in the sink environment and newborns in a NICU was investigated. More than 500 sink drain and faucet samples were collected over the course of five sampling campaigns undertaken over 3 years. Distribution and diversity of S. marcescens were examined with a modified MacConkey medium and a high-throughput short-sequence typing (HiSST) method. Sink drains were an important reservoir of S. marcescens, with an average of 44% positive samples, whereas no faucet sample was positive. The genotypic diversity of S. marcescens was moderate, with an average of two genotypes per drain, while the spatial distribution of S. marcescens was heterogeneous. The genotypic profiles of 52 clinical isolates were highly heterogeneous, with 27 unique genotypes, of which 71% of isolates were found in more than one patient. S. marcescens acquisition during the first outbreaks was mainly caused by horizontal transmissions. HiSST analyses revealed 10 potential cases of patient-to-patient transmission of S. marcescens, five cases of patient-to-sink transmission, and one bidirectional transfer between sink and patient. Environmental and clinical isolates were found in sink drains up to 1 year after the first detection, supporting persisting drain colonization. This extensive survey suggests multiple reservoirs of S. marcescens within the NICU, including patients and sink drains, but other external sources should also be considered.
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Registered trials
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