Evidence map›Paper›PMID 37067199›Full record

ReviewCancer discovery2023

Converging on a Cure: The Roads to Predictive Immunotherapy.

Genevieve L Stein-O'Brien, Dung T Le, Elizabeth M Jaffee, Elana J Fertig, Neeha Zaidi

Open access · greenAbstract readReview
In one paragraph

Review in Cancer discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Real-world data and evidence: pioneering frontiers in precision oncology.Journal of Zhejiang University. Science. B · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Genevieve L Stein-O'BrienJohns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-8681-9110
Dung T LeJohns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-2110-7697
Elizabeth M JaffeeJohns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3841-6549
Elana J FertigJohns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3204-342X
Neeha ZaidiJohns Hopkins Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-0094-0049
Bloomberg (United States) · USJohns Hopkins University · US

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6M
Transforming Human Pancreatic Cancer Into An Immunologic DiseaseP01CA247886 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A. · 2021 to 2025
$12.7M
Project 3: Inhibiting Oxidative Phosphorylation in Pancreatic CancerP50CA221707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOPETZ, SCOTT, MAITRA, ANIRBAN · 2019 to 2023
$11.0M
Tumor Microenvironment Crosstalk Drives Early Lesions in Pancreatic CancerU54CA274371 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIRBAN MAITRA, Marina Pasca Di Magliano · 2022 to 2026
$9.5M
Targeting the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer with a Neoadjuvant Platform Clinical TrialR01CA197296 · NCI · JOHNS HOPKINS UNIVERSITY · PI William Reece Burns, Eric Christenson · 2015 to 2026
$5.7M
Integrating bioinformatics into multiscale models for hepatocellular carcinomaU01CA212007 · NCI · JOHNS HOPKINS UNIVERSITY · PI EWALD, ANDREW JOSEF, FERTIG, ELANA · 2018 to 2022
$3.2M
Interrogation of the Impact of Selection on the Evolution of Human PancreaticCancer Precursor LesionsU01CA271273 · NCI · JOHNS HOPKINS UNIVERSITY · PI Elana Fertig, Rachel Karchin · 2022 to 2026
$2.8M
Mutant KRAS targeted vaccines for the interception of pancreatic cancer developmentR37CA292056 · NCI · JOHNS HOPKINS UNIVERSITY · PI Neeha Zaidi · 2024 to 2026
$2.0M
Single-cell and imaging data integration software to spatially resolve the tumor microenvironmentU01CA253403 · NCI · JOHNS HOPKINS UNIVERSITY · PI FERTIG, ELANA · 2020 to 2022
$1.2M
Neoantigen-Targeted Vaccines in Combination with Immune Checkpoint Inhibitors for Pancreatic CancerK08CA248624 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZAIDI, NEEHA · 2021 to 2025
$1.1M
Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space MethodsR00NS122085 · NINDS · JOHNS HOPKINS UNIVERSITY · PI STEIN-O'BRIEN, GENEVIEVE LAUREN · 2023 to 2025
$697k
Resolving Spatiotemporal Determinants of Cell Specification in Corticogenesis with Latent Space MethodsK99NS122085 · NINDS · JOHNS HOPKINS UNIVERSITY · PI STEIN-O'BRIEN, GENEVIEVE LAUREN · 2021 to 2022
$221k
NCI NIH HHS K08 CA248624NCI NIH HHS P01 CA247886NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA221707NCI NIH HHS R01 CA197296NCI NIH HHS R37 CA292056NCI NIH HHS U01 CA212007NCI NIH HHS U01 CA253403NCI NIH HHS U01 CA271273NCI NIH HHS U54 CA274371NINDS NIH HHS K99 NS122085NINDS NIH HHS R00 NS122085
6 · The paper itself

Abstract

summaryConvergence science teams integrating clinical, biological, engineering, and computational expertise are inventing new forecast systems to monitor and predict evolutionary changes in tumor and immune interactions during early cancer progression and therapeutic response. The resulting methods should inform a new predictive medicine paradigm to select adaptive immunotherapeutic regimens personalized to patients' tumors at a given time during their cancer progression for durable patient response.

Indexed as

ImmunotherapyNeoplasmsPrecision MedicineDrug ResistanceHumansTumor Microenvironment

Identifiers

PMID37067199
PMCPMC10548443
OpenAlexW4366082763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.