ArticleeLife2023
Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and neurodegeneration stratified by sex.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mortality, functional outcome, and bleeding risk after early versus delayed thrombectomy.GeroScience · 2026Pooled it
- Sex differences inFrontiers in dementia · 2025Pooled it
- Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old.GeroScience · 2026Article
- A Lightweight ScaleDense-Transformer Framework with Auxiliary Quantum-Inspired Bottleneck Module for Whole-Lifespan Brain Age Prediction.Brain sciences · 2026Article
- Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of studies using ADNI data (2023 to June 2025).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Association of hippocampus, entorhinal cortex, and amygdala with thyroid function: a bilateral volumetric analysis.Thyroid research · 2026Article
- Longitudinal brain-age predictions comprising long-duration spaceflight missions.NPJ microgravity · 2026Article
- Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain Age as a Biomarker in Alzheimer's Disease: Narrative Perspectives on Imaging, Biomarkers, Machine Learning, and Intervention Potential.Brain sciences · 2025Review
- Distributed fMRI patterns coupled to low-frequency cardiorespiratory dynamics provide markers of aging.bioRxiv : the preprint server for biology · 2025Article
- Hidden risk: Latent cognitive profiles and structural brain age reveal vulnerability in midlife metabolic syndrome.Journal of the International Neuropsychological Society : JINS · 2025Article
- Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.Molecular psychiatry · 2025Article
- Does restrictive anorexia nervosa impact brain aging? A machine learning approach to estimate age based on brain structure.Computers in biology and medicine · 2025Article
- BrainAge moderates associations between Alzheimer's disease biomarkers and cognitive decline: a meta-analysis across A4/LEARN, HABS and ADNI cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Volumetric Changes in Cerebellar Transverse Zones: Age and Sex Effects in Health and Neurological Disorders.Human brain mapping · 2025Article
- Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study.Frontiers in aging neuroscience · 2025Article
- Accelerometer-Measured Physical Activity and Neuroimaging-Driven Brain Age.Health data science · 2025Article
- Machine learning applied to mild cognitive impairment: bibliometric and visual analysis from 2015 to 2024.Frontiers in neurology · 2025Review
- Longitudinal brain ageing after stroke: a marker for neurodegeneration and its relevance for upper limb motor outcome.Brain communications · 2025Article
- Metadata-conditioned generative models to synthesize anatomically-plausible 3D brain MRIs.Medical image analysis · 2024Article
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Authors and funding
31 authors.
Funding
Abstract
Brain-age can be inferred from structural neuroimaging and compared to chronological age (brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in neurodegenerative disorders like Alzheimer's disease (AD), but its validation against markers of neurodegeneration and AD is lacking. Here, imaging-derived measures from the UK Biobank dataset (N=22,661) were used to predict brain-age in 2,314 cognitively unimpaired (CU) individuals at higher risk of AD and mild cognitive impaired (MCI) patients from four independent cohorts with available biomarker data: ALFA+, ADNI, EPAD, and OASIS. Brain-age delta was associated with abnormal amyloid-β, more advanced stages (AT) of AD pathology and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.