Evidence map›Paper›PMID 37066921›Full record

ArticleJournal of Parkinson's disease2023

Quantitative Sleep Electroencephalogram in Parkinson's Disease: A Case-Control Study.

Adeel A Memon, Corina Catiul, Zachary Irwin, Jennifer Pilkington, Raima A Memon, Allen Joop, Kimberly H Wood, Gary Cutter, Svjetlana Miocinovic, Amy W Amara

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Adeel A MemonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Corina CatiulDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Zachary IrwinNeuroengineering Ph.D. program, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer PilkingtonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Raima A MemonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Allen JoopDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Kimberly H WoodDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Gary CutterDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Svjetlana MiocinovicDepartment of Neurology, Emory University, Atlanta, GA, USA.
Amy W AmaraDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
University of Alabama at Birmingham · USEmory University · USWest Virginia University · US

Funding

Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8M
Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's diseaseR01HD100670 · NICHD · UNIVERSITY OF COLORADO DENVER · PI AMARA, AMY WILLIS · 2021 to 2025
$3.0M
UAB Research Education Program for Residents and Fellows in NeuroscienceR25NS079188 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STANDAERT, DAVID G. · 2012 to 2022
$1.1M
Targeted activation of select neural pathways by deep brain stimulation in patients with Parkinson's diseaseK23NS097576 · NINDS · EMORY UNIVERSITY · PI MIOCINOVIC, SVJETLANA · 2016 to 2021
$1.1M
The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD PatientsK23NS080912 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMARA, AMY WILLIS · 2012 to 2016
$934k
NICHD NIH HHS R01 HD100670NICHD NIH HHS T32 HD071866NINDS NIH HHS K23 NS080912NINDS NIH HHS K23 NS097576NINDS NIH HHS R25 NS079188
6 · The paper itself

Abstract

backgroundSleep disorders are common in Parkinson's disease (PD) and include alterations in sleep-related EEG oscillations.

objectiveThis case-control study tested the hypothesis that patients with PD would have a lower density of Scalp-Slow Wave (SW) oscillations and higher slow-to-fast frequencies ratio in rapid eye movement (REM) sleep than non-PD controls. Other sleep-related quantitative EEG (qEEG) features were also examined, including SW morphology, sleep spindles, and Scalp-SW spindle phase-amplitude coupling.

methodsPolysomnography (PSG)-derived sleep EEG was compared between PD participants (n = 56) and non-PD controls (n = 30). Following artifact rejection, sleep qEEG analysis was performed in frontal and central leads. Measures included SW density and morphological features of SW and sleep spindles, SW-spindle phase-amplitude coupling, and spectral power analysis in Non-REM (NREM) and REM. Differences in qEEG features between PD and non-PD controls were compared using two-tailed Welch's t-tests, and correction for multiple comparisons was performed per the Benjamini-Hochberg method.

resultsSW density was lower in PD than in non-PD controls (F = 13.5, p' = 0.003). The PD group also exhibited higher ratio of slow REM EEG frequencies (F = 4.23, p' = 0.013), higher slow spindle peak frequency (F = 24.7, p' < 0.002), and greater SW-spindle coupling angle distribution non-uniformity (strength) (F = 7.30, p' = 0.034).

conclusionThis study comprehensively evaluates sleep qEEG including SW-spindle phase amplitude coupling in PD compared to non-PD controls. These findings provide novel insights into how neurodegenerative disease disrupts electrophysiological sleep rhythms. Considering the role of sleep oscillatory activity on neural plasticity, future studies should investigate the influence of these qEEG markers on cognition in PD.

Indexed as

Neurodegenerative DiseasesParkinson DiseaseCase-Control StudiesElectroencephalographyHumansSleepnon-rapid eye movement sleepParkinson’s diseasephase-amplitude couplingquantitative sleep EEGrapid eye movement sleepsleep spindlesslow waves

Identifiers

PMID37066921
PMCPMC10200139
OpenAlexW4364361020

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.