Evidence map›Paper›PMID 37066412›Full record

ArticlebioRxiv : the preprint server for biology2023

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.

Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta and 26 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 19 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

36 authors at 7 institutions in 2 countries.

Linda T Nieman
Maxwell Spurrell
Vjola Jorgji
Peter Richieri
Katherine H Xu
Roopa Madhu
Milan Parikh
Izabella Zamora
Arnav Mehta
Christopher S Nabel
Samuel S Freeman
Joshua D Pirl
Chenyue Lu
Catherine B Meador
Jaimie L Barth
Mustafa Sakhi
Alexander L Tang
Siranush Sarkizova
Colles Price
Nicolas F Fernandez
George Emanuel
Jiang He
Katrina Van Raay
Jason W Reeves
Keren Yizhak
Matan Hofree
Angela Shih
Moshe Sade-Feldman
Genevieve M Boland
Karin Pelka
Martin Aryee
Ilya Korsunsky
Mari Mino-Kenudson
Justin F Gainor
Nir Hacohen
Broad Institute · USHarvard University · USRepligen (United States) · USNanostring Technologies (United States) · USBrigham and Women's Hospital · USMGH Institute of Health Professions · USTechnion – Israel Institute of Technology · IL

Funding

Training Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8M
NHGRI NIH HHS T32 HG002295
6 · The paper itself

Abstract

The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines

Identifiers

PMID37066412
PMCPMC10104028
OpenAlexW4362663294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.