Evidence map›Paper›PMID 37066411›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Genome-wide association study in 404,302 individuals identifies 7 significant loci for reaction time variability.

Olivia Wootton, Alexey A Shadrin, Christine Mohn, Ezra Susser, Raj Ramesar, Ruben C Gur, Ole A Andreassen, Dan J Stein, Shareefa Dalvie

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Olivia WoottonDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, South Africa.
Alexey A ShadrinNorwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Christine MohnNorwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ezra SusserDepartment of Epidemiology, Mailman School of Public Health, Columbia University, USA.
Raj RamesarUCT MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Institute of Infectious Diseases and Molecular Medicine and University of Cape Town, Cape Town, South Africa.
Ruben C GurBrain Behavior Laboratories, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, USA.
Ole A AndreassenNorwegian Centre for Mental Disorders Research, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Dan J SteinDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, South Africa.
Shareefa DalvieDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, South Africa.
Oslo University Hospital · NOSouth African Medical Research Council · ZANew York Psychoanalytic Society and Institute · USUniversity of Cape Town · ZAUniversity of Pennsylvania · US

Funding

3/3 Genomics of Schizophrenia in the South African XhosaU01MH125053 · NIMH · UNIVERSITY OF CAPE TOWN · PI STEIN, DAN JOSEPH · 2021 to 2025
$3.5M
3/3 GENOMICS OF SCHIZOPHRENIA IN THE SOUTH AFRICAN XHOSAU01MH096754 · NIMH · UNIVERSITY OF CAPE TOWN · PI STEIN, DAN JOSEPH · 2013 to 2017
$3.2M
The Ancestral Populations Network Phenotypic Harmonization Working Group Administrative Supplement: 2/3 Genomics of Schizophrenia in the South African XhosaU01MH125058 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WALL, MELANIE M · 2021 to 2025
$2.5M
NIMH NIH HHS U01 MH096754NIMH NIH HHS U01 MH125053NIMH NIH HHS U01 MH125058
6 · The paper itself

Abstract

Reaction time variability (RTV), reflecting fluctuations in response time on cognitive tasks, has been proposed as an endophenotype for many neuropsychiatric disorders. There have been no large-scale genome wide association studies (GWAS) of RTV and little is known about its genetic underpinnings. Here, we used data from the UK Biobank to conduct a GWAS of RTV in participants of white British ancestry (

Identifiers

PMID37066411
PMCPMC10104187
OpenAlexW4362543314

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.