ArticlebioRxiv : the preprint server for biology2023
Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate.
Onur Ertunc, Erica Smearman, Qizhi Zheng, Jessica L Hicks, Jacqueline A Brosnan-Cashman, Tracy Jones, Carolina Gomes-Alexandre, Levent Trabzonlu, Alan K Meeker, Angelo M De Marzo and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 2 institutions in 1 country.
Onur ErtuncThe Department of Pathology, The Johns Hopkins University School of Medicine.
Erica SmearmanThe Department of Pathology, The Johns Hopkins University School of Medicine.
Qizhi ZhengThe Department of Pathology, The Johns Hopkins University School of Medicine.
Jessica L HicksThe Department of Pathology, The Johns Hopkins University School of Medicine.
Jacqueline A Brosnan-CashmanThe Department of Pathology, The Johns Hopkins University School of Medicine.
Tracy JonesThe Department of Pathology, The Johns Hopkins University School of Medicine.
Carolina Gomes-AlexandreThe Department of Pathology, The Johns Hopkins University School of Medicine.
Levent TrabzonluThe Department of Pathology, The Johns Hopkins University School of Medicine.
Alan K MeekerThe Department of Pathology, The Johns Hopkins University School of Medicine.
Angelo M De MarzoThe Department of Pathology, The Johns Hopkins University School of Medicine.
Christopher M HeaphyThe Department of Medicine, Boston University, School of Medicine and Boston Medical Center, Boston, Massachusetts.
Johns Hopkins University · USBoston University · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MTRANSGENIC MODELS FOR PROSTATE CANCER AND AUTOIMMUNITYP50CA058236 · NCI · JOHNS HOPKINS UNIVERSITY · PI NELSON, WILLIAM GEORGE · 1992 to 2020
$43.9MTranslational imaging biomarkers of the tumor microenvironment in early prostate cancerU54CA274370 · NCI · JOHNS HOPKINS UNIVERSITY · PI Alexander S Szalay · 2022 to 2026
$9.1MMultidiciplinary Integrative Genomic Approach to Distinguish Lethal from Indolent Prostate Cancer in Men of Europena and African AncestryU01CA196390 · NCI · JOHNS HOPKINS UNIVERSITY · PI DE MARZO, ANGELO MICHAEL, PIENTA, KENNETH J. · 2015 to 2020
$5.8MNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA058236NCI NIH HHS U01 CA196390NCI NIH HHS U54 CA274370
6 · The paper itselfAbstract
Telomeres are terminal chromosomal elements that are essential for the maintenance of genomic integrity. The measurement of telomere content provides useful diagnostic and prognostic information, and fluorescent methods have been developed for this purpose. However, fluorescent-based tissue assays are cumbersome for investigators to undertake, both in research and clinical settings. Here, a robust chromogenic
Indexed as
chromogenicin situ hybridizationprostate cancerTelomeres
Identifiers
PMID37066381
PMCPMC10104079
OpenAlexW4362677504
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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