Evidence map›Paper›PMID 37066378›Full record

ArticlebioRxiv : the preprint server for biology2023

Dynein-Powered Cell Locomotion Guides Metastasis of Breast Cancer.

Yerbol Tagay, Sina Kheirabadi, Zaman Ataie, Rakesh K Singh, Olivia Prince, Ashley Nguyen, Alexander S Zhovmer, Xuefei Ma, Amir Sheikhi, Denis Tsygankov and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yerbol TagayDepartment of Pharmacology, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Sina KheirabadiDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Zaman AtaieDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Rakesh K SinghDepartment of Obstetrics & Gynecology, University of Rochester Medical Center, Rochester, NY, USA.
Olivia PrinceCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20903, USA.
Ashley NguyenCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20903, USA.
Alexander S ZhovmerCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20903, USA.
Xuefei MaCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20903, USA.
Amir SheikhiDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Denis TsygankovWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Erdem D TabdanovDepartment of Pharmacology, Penn State College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA.
Pennsylvania State University · USCenter for Biologics Evaluation and Research · USGeorgia Institute of Technology · USUniversity of Rochester Medical Center · US

Funding

Coordinated Actin Regulation in Directed Neural Crest Cell MigrationR01GM136892 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI NIE, SHUYI · 2020 to 2024
$1.6M
NIGMS NIH HHS R01 GM136892
6 · The paper itself

Abstract

Metastasis is a principal cause of death in cancer patients, which remains an unresolved fundamental and clinical problem. Conventionally, metastatic dissemination is linked to the actomyosin-driven cell locomotion. However, locomotion of cancer cells often does not strictly line up with the measured actomyosin forces. Here, we identify a complementary mechanism of metastatic locomotion powered by the dynein-generated forces. These forces that arise within a non-stretchable microtubule network drive persistent contact guidance of migrating cancer cells along the biomimetic collagen fibers. We also show that dynein-powered locomotion becomes indispensable during invasive 3D migration within a tissue-like luminal network between spatially confining hydrogel microspheres. Our results indicate that the complementary contractile system of dynein motors and microtubules is always necessary and in certain instances completely sufficient for dissemination of metastatic breast cancer cells. These findings advance fundamental understanding of cell locomotion mechanisms and expand the spectrum of clinical targets against metastasis.

Identifiers

PMID37066378
PMCPMC10104034
OpenAlexW4362668642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.