Evidence map›Paper›PMID 37066360›Full record

ArticlebioRxiv : the preprint server for biology2023

Identification of LMAN1 and SURF4 dependent secretory cargoes.

Vi T Tang, Prabhodh S Abbineni, Felipe da Veiga Leprevost, Venkatesha Basrur, Brian T Emmer, Alexey I Nesvizhskii, David Ginsburg

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Vi T TangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI.
Prabhodh S AbbineniLife Sciences Institute, University of Michigan, Ann Arbor, MI.
Felipe da Veiga LeprevostDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Venkatesha BasrurDepartment of Pathology, University of Michigan, Ann Arbor, MI.
Brian T EmmerDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI.
Alexey I NesvizhskiiDepartment of Pathology, University of Michigan, Ann Arbor, MI.
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor, MI.
University of Michigan · USHoward Hughes Medical Institute · US

Funding

COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4M
The Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1M
Examining Molecular Regulation of Unconventional Cytoplasmic Protein SecretionK99GM141268 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABBINENI, PRABHODH SAI · 2021 to 2022
$200k
NHLBI NIH HHS R35 HL135793NIGMS NIH HHS K99 GM141268NIGMS NIH HHS R01 GM094231
6 · The paper itself

Abstract

Most proteins secreted into the extracellular space are first recruited from the endoplasmic reticulum into coat protein complex II (COPII)-coated vesicles or tubules that facilitate their transport to the Golgi apparatus. Although several secreted proteins have been shown to be actively recruited into COPII vesicles/tubules by the cargo receptors LMAN1 and SURF4, the full cargo repertoire of these receptors is unknown. We now report mass spectrometry analysis of conditioned media and cell lysates from HuH7 cells CRISPR targeted to inactivate the

Identifiers

PMID37066360
PMCPMC10104123
OpenAlexW4362700642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.