Evidence map›Paper›PMID 37066318›Full record

ArticlebioRxiv : the preprint server for biology2023

Spinal motoneurons respond aberrantly to serotonin in a rabbit model of cerebral palsy.

E J Reedich, L T Genry, P R Steele, E Mena Avila, L Dowaliby, A Drobyshevsky, M Manuel, K A Quinlan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

E J ReedichGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
L T GenryGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
P R SteeleGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
E Mena AvilaGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
L DowalibyGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
A DrobyshevskyNorthshore University Health System, Evanston, IL, USA.
M ManuelGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
K A QuinlanGeorge and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
University of Rhode Island · USNorthShore University HealthSystem · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Christopher Lee Hemme · 2012 to 2026
$63.6M
Impairment of Spinal Development in Cerebral PalsyR01NS104436 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2017 to 2026
$4.3M
Spinal serotonin in cerebral palsyR01NS091278 · NINDS · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DROBYSHEVSKY, ALEXANDER · 2015 to 2019
$1.7M
NIGMS NIH HHS P20 GM103430NINDS NIH HHS R01 NS091278NINDS NIH HHS R01 NS104436
6 · The paper itself

Abstract

Cerebral palsy (CP) is caused by a variety of factors that damage the developing central nervous system. Impaired motor control, including muscle stiffness and spasticity, is the hallmark of spastic CP. Rabbits that experience hypoxic-ischemic (HI) injury Key points: After prenatal hypoxia-ischemia (HI), neonatal rabbits that show hypertonia are known to have higher levels of spinal serotoninWe tested responsivity of spinal motoneurons (MNs) in neonatal control and HI rabbits to serotonin using whole cell patch clampMNs from HI rabbits showed a more robust excitatory response to serotonin than control MNs, including hyperpolarization of the persistent inward current and threshold for action potentials, larger post-inhibitory rebound, and less spike frequency adaptation Based on immunohistochemistry of lumbar MNs, fewer HI MNs express inhibitory 5HT

Identifiers

PMID37066318
PMCPMC10104065
OpenAlexW4362659841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.