Evidence map›Paper›PMID 37066317›Full record

ArticlemedRxiv : the preprint server for health sciences2023

White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer's disease continuum.

Lauren Rose Hirschfeld, Rachael Deardorff, Evgeny J Chumin, Yu-Chien Wu, Brenna C McDonald, Sha Cao, Shannon L Risacher, Dahyun Yi, Min Soo Byun, Jun-Young Lee and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Lauren Rose HirschfeldStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Rachael DeardorffIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Evgeny J ChuminIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Yu-Chien WuIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Brenna C McDonaldIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Sha CaoIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Shannon L RisacherIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Dahyun YiInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea, 03080.
Min Soo ByunDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea, 03080.
Jun-Young LeeDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, Korea, 03080.
Yu Kyeong KimDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea, 07061.
Koung Mi KangDepartment of Radiology, Seoul National University Hospital, Seoul, Korea, 03080.
Chul-Ho SohnDepartment of Radiology, Seoul National University Hospital, Seoul, Korea, 03080.
Kwangsik NhoIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Andrew J SaykinIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN USA, 46202.
Dong Young LeeInstitute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Korea, 03080.
KBASE Research Group
Indiana University School of MedicineSeoul National University · KRSeoul National University Hospital · KRIndiana University Bloomington · USIndiana University Health · USSNUH SMG-SNU Boramae Medical Center · KR

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Laurel A Beckett · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Mariet Allen · 2023 to 2026
$42.0M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems BiologyU01AG072177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LEE, DONG YOUNG, NHO, KWANGSIK TIMOTHY · 2021 to 2025
$11.2M
Memory Circuitry in MCI and Early Alzheimer’s Disease Prodrome: Molecular DriversR01AG019771 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 2001 to 2021
$6.9M
Leveraging Neuroimaging Biomarkers to Understand the Role of Social Networks in Alzheimer's DiseaseR01AG057739 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI APOSTOLOVA, LIANA G, PERRY, BREA LOUISE · 2018 to 2022
$3.5M
Multi-Domain Sensory Measures as Biomarkers of Alzheimer's Disease in Preclinical and Prodromal StagesR01AG061788 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI RISACHER, SHANNON L · 2019 to 2023
$3.0M
NIA NIH HHS F31 AG074700NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG061788NIA NIH HHS R01 AG068193NIA NIH HHS R37 AG057739NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG074879NIA NIH HHS U24 AG074855NLM NIH HHS R01 LM012535NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

backgroundWhite matter (WM) microstructural changes in the hippocampal cingulum bundle (CBH) in Alzheimer's disease (AD) have been described in cohorts of largely European ancestry but are lacking in other populations.

methodsWe assessed the relationship between CBH WM integrity and cognition or amyloid burden in 505 Korean older adults aged ≥55 years, including 276 cognitively normal older adults (CN), 142 mild cognitive impairment (MCI), and 87 AD, recruited as part of the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's disease (KBASE) at Seoul National University.

resultsCompared to CN, AD and MCI subjects showed decreased WM integrity in the bilateral CBH. Cognition, mood, and higher amyloid burden were also associated with poorer WM integrity in the CBH.

conclusionThese findings are consistent with patterns of WM microstructural damage previously reported in non-Hispanic White (NHW) MCI/AD cohorts, reinforcing existing evidence from predominantly NHW cohort studies.

Indexed as

Alzheimer’s diseaseCingulum bundle of the hippocampuscognitionmild cognitive impairmentwhite matter

Identifiers

PMID37066317
PMCPMC10104207
OpenAlexW4362700088

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.