Evidence map›Paper›PMID 37066309›Full record

ArticlebioRxiv : the preprint server for biology2023

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme.

Cheng-Guo Wu, Vijaya K Balakrishnan, Pankaj S Parihar, Kirill Konovolov, Yu-Chia Chen, Ronald A Merrill, Hui Wei, Bridget Carragher, Ramya Sundaresan, Qiang Cui and 9 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Cheng-Guo WuMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Vijaya K BalakrishnanMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Pankaj S PariharMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Kirill KonovolovChemistry Department, University of Wisconsin at Madison, Wisconsin 53706, USA.
Yu-Chia ChenMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Ronald A MerrillDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USA.
Hui WeiNew York Structural biology Center, New York, NY 10027, USA.
Bridget CarragherNew York Structural biology Center, New York, NY 10027, USA.
Ramya SundaresanMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Qiang CuiDepartment of Chemistry, Metcalf Center for Science & Engineering, Boston University, Boston, MA 02215, USA.
Brian E WadzinskiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Mark R SwingleDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA.
Alla MusiyenkoDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA.
Richard HonkanenDepartment of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY 10032, USA.
Aussie SuzukiMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
Stefan StrackDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USA.
Xuhui HuangBiophysics program, University of Wisconsin at Madison, Wisconsin 53706, USA.
Yongna XingMcArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin at Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
University of Wisconsin–Madison · USUniversity of Iowa · USUniversity of South Alabama · USNew York Structural Biology Center · USUniversity of Wisconsin System · USBoston University · USColumbia University · USVanderbilt University · US

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Chromosome dynamics and organizations necessary for faithful chromosome segregationR35GM147525 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aussie Suzuki · 2022 to 2026
$2.5M
Structural and Cellular Choreography for Decommissioning and Recycling of PP2A HoloenzymesR01GM137090 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI XING, YONGNA · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM137090NIGMS NIH HHS R35 GM147525NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

An increasing number of mutations associated with devastating human diseases are diagnosed by whole-genome/exon sequencing. Recurrent

Identifiers

PMID37066309
PMCPMC10103954
OpenAlexW4324053452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.