Evidence map›Paper›PMID 37066295›Full record

ArticlebioRxiv : the preprint server for biology2023

Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a NO-CCL2-CCR2 pathway.

Qi Ye, Juyeon Jo, Chih-Yen Wang, Heavin Oh, Tiffany J Choy, Kyoungin Kim, Angelo D'Alessandro, Yana K Reshetnyak, Sung Yun Jung, Zheng Chen and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qi YeDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Juyeon JoDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Chih-Yen WangDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Heavin OhDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Tiffany J ChoyJan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Kyoungin KimDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.
Yana K ReshetnyakPhysics Department, University of Rhode Island, Kingston, RI, USA.
Sung Yun JungDepartment of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.
Zheng ChenDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sean P MarrelliDepartment of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Hyun Kyoung LeeDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Denver · USUniversity of Rhode Island · US

Funding

UM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
TM INTERACTIONS IN MEMBRANE PROTEIN FOLDING AND FUNCTIONR01GM073857 · NIGMS · YALE UNIVERSITY · PI ANDREEV, OLEG A, ENGELMAN, DONALD M. · 2006 to 2023
$8.4M
Noradrenergic mechanisms in breathing and respiratory pathophysiologiesR01HL130249 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI RAY, RUSSELL S · 2016 to 2024
$5.3M
METABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6M
Deciphering the mechanisms of glia development and white matter injuryR01NS110859 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Hyun Kyoung Lee · 2019 to 2026
$3.2M
Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic StrokeR01NS126287 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Hyun Kyoung Lee · 2023 to 2026
$1.9M
NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS R01 HL130249NICHD NIH HHS P50 HD103555NIDDK NIH HHS R01 DK114356NIGMS NIH HHS R01 GM073857NINDS NIH HHS R01 NS110859NINDS NIH HHS R01 NS126287
6 · The paper itself

Abstract

Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests pH homeostasis is a new cellular mechanism important for BBB integrity. In the current study, we investigated the function of an astrocyte-specific pH regulator, Slc4a4, in BBB maintenance and repair. We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled with dysregulated arginine-NO metabolism after Slc4a4 deletion. Using a model of ischemic stroke, we found that loss of Slc4a4 exacerbates BBB disruption and reactive gliosis, which were both rescued by pharmacological or genetic inhibition of the NO-CCL2 pathway

Indexed as

Astrocyteblood-brain barrierCCL2ischemic strokeNitric oxidepH regulationSlc4a4

Identifiers

PMID37066295
PMCPMC10103986
OpenAlexW4362513062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.