ArticleResearch square2023
Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention.
Yue Huang, Yuan Liu, Nil Pandey, Shrey Shah, Aurea Simon-Soro, Jessica Hsu, Zhi Ren, Zhenting Xiang, Dongyeop Kim, Tatsuro Ito and 11 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
21 authors at 5 institutions in 2 countries.
Yue HuangUniversity of Pennsylvania.
Yuan LiuBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0213-606X Nil PandeyUniversity of Pennsylvania.
Shrey ShahUniversity of Pennsylvania.
Aurea Simon-SoroUniversity of Pennsylvania.
Zhenting XiangUniversity of Pennsylvania.
Tatsuro ItoBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Christine BuckleyIndiana University.
Faizan AlawiDepartment of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, USA.
Yong LiBiofilm Research Labs, Levy Center for Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sarah BoyerNorthwestern University.
Xingchen ZhaoNorthwestern University.
Domenick ZeroDepartment of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, USA.ORCID 0000-0001-7499-2282 David CormodeUniversity of Pennsylvania.
California University of Pennsylvania · USUniversity of Pennsylvania · USIndiana University – Purdue University Indianapolis · USIndiana University · USJeonbuk National University · KR
Funding
Biofilm Elimination and Caries Prevention using Multifunctional NanocatalystsR01DE025848 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2017 to 2025
$5.6MAcquisition of a K2 Camera for Soft Matter Transmission Electron MicroscopyS10OD026871 · OD · NORTHWESTERN UNIVERSITY · PI GIANNESCHI, NATHAN CLAUDE · 2019 to 2019
$663kAdvanced Training at the Interface of Engineering and Oral-Craniofacial SciencesR90DE031532 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN, STEBE, KATHLEEN J · 2021 to 2025
$505kNIDCR NIH HHS R01 DE025848NIDCR NIH HHS R90 DE031532NIH HHS S10 OD026871
6 · The paper itselfAbstract
Dental caries (tooth decay) is the most prevalent human disease caused by oral biofilms, affecting nearly half of the global population despite increased use of fluoride, the mainstay anticaries (tooth-enamel protective) agent. Recently, an FDA-approved iron oxide nanozyme formulation (ferumoxytol, Fer) has been shown to disrupt caries-causing biofilms with high specificity via catalytic activation of hydrogen peroxide, but it is incapable of interfering with enamel acid demineralization. Here, we find notable synergy when Fer is combined with stannous fluoride (SnF
Identifiers
PMID37066293
PMCPMC10104273
OpenAlexW4362575053
What OpenQuestion holds
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LicenceCC BY
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