Evidence map›Paper›PMID 37066234›Full record

ArticlebioRxiv : the preprint server for biology2023

TREM2 mediates MHCII-associated CD4

Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Wenjing Zhang, Yuzhou Chang, Aastha Dheer, Shan Gao, Shengze Xu, Katayoun Ayasoufi, Rawan Al-Kharboosh and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Jiaying ZhengDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Lingxiao WangDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Shunyi ZhaoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Wenjing ZhangMayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, USA.
Yuzhou ChangDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Aastha DheerDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Shan GaoMayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, USA.
Shengze XuDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Rawan Al-KharbooshMayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, USA.
Manling XieDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Aaron J JohnsonDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Haidong DongDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Alfredo Quiñones-HinojosaDepartment of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA.
Long-Jun WuDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic · USMayo Clinic in Florida · US

Funding

Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy - SupplementRF1NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2021 to 2023
$2.0M
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and TauopathyR01NS122174 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2024 to 2025
$1.2M
Neuroprotective function of microglial TREM2 in TDP43-related neurodegenerationR21AG064159 · NIA · MAYO CLINIC ROCHESTER · PI WU, LONG-JUN · 2020 to 2020
$239k
Nervous system control and regulation of the immune system following neurological insultsK99NS117799 · NINDS · MAYO CLINIC ROCHESTER · PI AYASOUFI, KATAYOUN · 2021 to 2022
$209k
NIA NIH HHS R21 AG064159NINDS NIH HHS K99 NS117799NINDS NIH HHS R01 NS122174
6 · The paper itself

Abstract

Triggering receptor expressed on myeloid cells 2 (TREM2) was recently highlighted as a novel immune suppressive marker in peripheral tumors. The aim of this study was to characterize

Indexed as

gliomaTREM2tumor-associated macrophages

Identifiers

PMID37066234
PMCPMC10104080
OpenAlexW4362678476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.