Evidence map›Paper›PMID 37066210›Full record

ArticlebioRxiv : the preprint server for biology2023

A zinc finger transcription factor tunes social behaviors by controlling transposable elements and immune response in prefrontal cortex.

Natalie L Truby, R Kijoon Kim, Gabriella M Silva, Xufeng Qu, Joseph A Picone, Rebecca Alemu, Rachael L Neve, Xiaohong Cui, Jinze Liu, Peter J Hamilton

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Natalie L TrubyDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
R Kijoon KimDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Gabriella M SilvaDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Xufeng QuDepartment of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Joseph A PiconeDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Rebecca AlemuDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Rachael L NeveGene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA, USA.
Xiaohong CuiDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jinze LiuDepartment of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Peter J HamiltonDepartment of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Virginia Commonwealth University · USMassachusetts General Hospital · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI YAN ZHANG · 2014 to 2026
$13.8M
Using CRISPR tools to uncover the role of CREB-gene regulation in drug abuseR00DA045795 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAMILTON, PETER JAMES · 2020 to 2022
$739k
NCI NIH HHS P30 CA016059NIDA NIH HHS P30 DA033934NIDA NIH HHS R00 DA045795
6 · The paper itself

Abstract

The neurobiological origins of social behaviors are incompletely understood. Here we utilized synthetic biology approaches to reprogram the function of ZFP189, a transcription factor whose expression and function in the rodent prefrontal cortex was previously determined to be protective against stress-induced social deficits. We created novel synthetic ZFP189 transcription factors including ZFP189

Identifiers

PMID37066210
PMCPMC10103968
OpenAlexW4362575261

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.