Evidence map›Paper›PMID 37066205›Full record

ArticlebioRxiv : the preprint server for biology2023

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model.

Payton Martinez, Genna Nault, Jenna Steiner, Michael F Wempe, Angela Pierce, Breaunna Brunt, Mathew Slade, Andrew Mongin, Jane Song, Kang-Ho Song and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Payton MartinezORCID 0000-0003-2634-9502
Genna Nault
Jenna Steiner
Michael F Wempe
Angela Pierce
Breaunna Brunt
Mathew Slade
Andrew Mongin
Jane Song
Kang-Ho Song
Nicholas Ellens
Natalie Serkova
Adam Green
Mark Borden
University of Colorado Boulder · USMorgan Adams Foundation · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Bruker 9.4T/ 20cm BioSpec MR Scanner for Colorado Animal Imaging Shared ResourcesS10OD023485 · OD · UNIVERSITY OF COLORADO DENVER · PI SERKOVA, NATALIE J. · 2017 to 2017
$2.0M
Microbubble Dose Optimization for Image-Guided Drug DeliveryR01CA239465 · NCI · UNIVERSITY OF COLORADO · PI BORDEN, MARK ANDREW · 2019 to 2023
$1.7M
NCI NIH HHS R01 CA239465NIH HHS S10 OD023485
6 · The paper itself

Abstract

Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest pediatric brainstem tumor and is difficult to treat with chemotherapy in part due to the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubbles (MBs) have been shown to cause BBB disruption (BBBD), allowing larger chemotherapeutics to enter the parenchyma. Panobinostat is an example of a promising One Sentence Summary: FUS and microbubbles can increase the delivery of panobinostat to a patient-derived xenograft (PDX) orthotopic DMG tumor, providing a strong therapeutic effect and increased survival.

Identifiers

PMID37066205
PMCPMC10104021
OpenAlexW4362661843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.