Evidence map›Paper›PMID 37066201›Full record

ArticlebioRxiv : the preprint server for biology2023

Preclinical Screening of Splice-Switching Antisense Oligonucleotides in PDAC Organoids.

Ledong Wan, Alexander J Kral, Dillon Voss, Adrian R Krainer

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ledong Wan
Alexander J Kral
Dillon Voss
Adrian R Krainer
Cold Spring Harbor Laboratory · US

Funding

VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI Camila dos Santos · 1985 to 2026
$116.8M
Inducing PKM splice-switching with antisense oligonucleotides as an approach to treat hepatocellular carcinomaF30CA271804 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI VOSS, DILLON MATTHEW · 2022 to 2025
$175k
NCI NIH HHS F30 CA271804NCI NIH HHS P01 CA013106
6 · The paper itself

Abstract

Aberrant alternative splicing is emerging as a cancer hallmark and a potential therapeutic target. It is the result of dysregulated splicing factors or genetic alterations in splicing-regulatory

Identifiers

PMID37066201
PMCPMC10103938
OpenAlexW4362512533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.