Evidence map›Paper›PMID 37066191›Full record

ArticlebioRxiv : the preprint server for biology2023

Stepwise design of pseudosymmetric protein hetero-oligomers.

Ryan D Kibler, Sangmin Lee, Madison A Kennedy, Basile I M Wicky, Stella M Lai, Marius M Kostelic, Xinting Li, Cameron M Chow, Lauren Carter, Vicki H Wysocki and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ryan D KiblerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Sangmin LeeDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Madison A KennedyDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Basile I M WickyDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Stella M LaiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Marius M KostelicDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Cameron M ChowDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Lauren CarterDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Vicki H WysockiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Barry L StoddardDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98006, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2018 to 2022
$7.6M
MegaTALS: hyperspecific reagents for targeted gene modification and correctionR01GM105691 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STODDARD, BARRY L. · 2014 to 2022
$2.7M
Combined computational and structural studies to create novel macromolecular recognition propertiesR01GM139752 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STODDARD, BARRY L. · 2021 to 2023
$1.1M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Pilatus 6mS10OD021832 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ADAMS, PAUL DAVID · 2016 to 2016
$980k
NIAID NIH HHS HHSN272201700059CNIGMS NIH HHS P30 GM124169NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM105691NIGMS NIH HHS R01 GM139752NIH HHS S10 OD018483NIH HHS S10 OD021832
6 · The paper itself

Abstract

Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such proteins

Identifiers

PMID37066191
PMCPMC10104133

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.