Evidence map›Paper›PMID 37066171›Full record

ArticlebioRxiv : the preprint server for biology2023

Histone Deacetylases (HDACs) maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and non-coding loci.

Kelly Rdw, Stengel Kr, Chandru A, Johnson Lc, Hiebert Sw, Cowley Sm

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Kelly RdwDepartment of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK.
Stengel KrAlbert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue Chanin Building, Bronx, NY 10461.
Chandru ACancer Research UK Beatson Institute, Switchback Road, Bearsden, Glasgow, G61 1BD.
Johnson LcLocate Bio Limited, MediCity, Thane Road, Beeston, Nottingham, NG90 6BH.
Hiebert SwDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Cowley SmDepartment of Molecular and Cell Biology, Henry Wellcome Building, University of Leicester, Leicester, LE1 9HN, UK.
University of Leicester · GBAlbert Einstein College of Medicine · USCancer Research UK Scotland Institute · GBLocate Bio (United Kingdom) · GBVanderbilt University · US

Funding

Role of AML1-ETO in Acute LeukemiaR01CA064140 · NCI · VANDERBILT UNIVERSITY · PI HIEBERT, SCOTT W · 1994 to 2018
$5.7M
Hdac3 as a therapeutic target in BCL6-dependent lymphomaR01CA164605 · NCI · VANDERBILT UNIVERSITY · PI HIEBERT, SCOTT W · 2012 to 2022
$3.9M
Medical Research Council MR/J009202/1NCI NIH HHS R01 CA064140NCI NIH HHS R01 CA164605
6 · The paper itself

Abstract

Histone acetylation is a dynamic modification regulated by the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Deacetylation of histone tails results in chromatin tightening and therefore HDACs are generally regarded as transcriptional repressors. Counterintuitively, simultaneous deletion of

Identifiers

PMID37066171
PMCPMC10104071
OpenAlexW4362700777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.