Evidence map›Paper›PMID 37066145›Full record

ArticlebioRxiv : the preprint server for biology2023

Control of working memory maintenance by theta-gamma phase amplitude coupling of human hippocampal neurons.

Jonathan Daume, Jan Kaminski, Andrea G P Schjetnan, Yousef Salimpour, Umais Khan, Chrystal Reed, William Anderson, Taufik A Valiante, Adam N Mamelak, Ueli Rutishauser

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jonathan DaumeDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jan KaminskiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Andrea G P SchjetnanKrembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada.
Yousef SalimpourDepartment of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Umais KhanDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Chrystal ReedDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
William AndersonDepartment of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Taufik A ValianteKrembil Research Institute and Division of Neurosurgery, University Health Network (UHN), University of Toronto, Toronto, ON, Canada.
Adam N MamelakDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

Neuronal mechanisms of human episodic memoryU01NS117839 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2020 to 2024
$7.8M
Neuronal mechanisms of human episodic memoryU01NS103792 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2017 to 2019
$3.5M
Single-neuron mechanisms of executive control of long-term memory processes in humansR01MH110831 · NIMH · CEDARS-SINAI MEDICAL CENTER · PI RUTISHAUSER, UELI · 2016 to 2020
$2.2M
NIMH NIH HHS R01 MH110831NINDS NIH HHS U01 NS103792NINDS NIH HHS U01 NS117839
6 · The paper itself

Abstract

Retaining information in working memory (WM) is a demanding process that relies on cognitive control to protect memoranda-specific persistent activity from interference. How cognitive control regulates WM storage, however, remains unknown. We hypothesized that interactions of frontal control and hippocampal persistent activity are coordinated by theta-gamma phase amplitude coupling (TG-PAC). We recorded single neurons in the human medial temporal and frontal lobe while patients maintained multiple items in WM. In the hippocampus, TG-PAC was indicative of WM load and quality. We identified cells that selectively spiked during nonlinear interactions of theta phase and gamma amplitude. These PAC neurons were more strongly coordinated with frontal theta activity when cognitive control demand was high, and they introduced information-enhancing and behaviorally relevant noise correlations with persistently active neurons in the hippocampus. We show that TG-PAC integrates cognitive control and WM storage to improve the fidelity of WM representations and facilitate behavior.

Identifiers

PMID37066145
PMCPMC10104113

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.