Evidence map›Paper›PMID 37066107›Full record

ReviewNeurology. Clinical practice2023

Association of Early Seizure Prophylaxis With Posttraumatic Seizures and Mortality: A Meta-analysis With Evidence Quality Assessment.

Lilian Maria Godeiro Coelho, Deborah Blacker, John Hsu, Joseph P Newhouse, M Brandon Westover, Sahar F Zafar, Lidia M V R Moura

Erratum issuedOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology. Clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Frequency of seizures in post-cerebrovascular accident patients.Pakistan journal of medical sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Correction to Author Disclosures.Neurology. Clinical practice · 2025
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lilian Maria Godeiro CoelhoDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
Deborah BlackerDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
John HsuDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
Joseph P NewhouseDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
M Brandon WestoverDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.ORCID https://orcid.org/0000-0003-4803-312X
Sahar F ZafarDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
Lidia M V R MouraDepartment of Neurology (LMGC, MBW, SFZ, LMVRM), Massachusetts General Hospital; Department of Neurology (MBW, SFZ, LMVRM), Harvard Medical School; Department of Epidemiology (DB), Harvard T.H. Chan School of Public Health; Department of Psychiatry (DB), Massachusetts General Hospital; Department of Psychiatry (DB), Harvard Medical School; Department of Health Care Policy (JH, JPN), Harvard Medical School; Mongan Institute (JH), Massachusetts General Hospital; Department of Medicine (JH), Harvard Medical School, Boston; National Bureau of Economic Research (JPN), Cambridge; Department of Health Policy and Management (JPN), Harvard T.H. Chan School of Public Health, Boston; and Harvard Kennedy School (JPN), Cambridge, MA.
National Bureau of Economic Research · US

Funding

Tradeoffs in the Design of Public Long-Term Care BenefitsP01AG032952 · NIA · HARVARD MEDICAL SCHOOL · PI Bruce E. Landon · 2009 to 2026
$39.0M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1M
NIA NIH HHS P01 AG032952NIA NIH HHS R01 AG073410
6 · The paper itself

Abstract

Purpose of the Review: To evaluate the quality of evidence about the association of primary seizure prophylaxis with antiseizure medication (ASM) within 7 days postinjury and the 18- or 24-month epilepsy/late seizure risk or all-cause mortality in adults with new-onset traumatic brain injury (TBI), in addition to early seizure risk. Results: Twenty-three studies met the inclusion criteria (7 randomized and 16 nonrandomized studies). We analyzed 9,202 patients, including 4,390 in the exposed group and 4,812 in the unexposed group (894 in placebo and 3,918 in no ASM groups). There was a moderate to serious bias risk based on our assessment. Within the limitations of existing studies, our data revealed a lower risk for early seizures in the ASM prophylaxis group compared with placebo or no ASM prophylaxis (risk ratio [RR] 0.43, 95% confidence interval [CI] 0.33-0.57, Summary: Our data suggest that the evidence showing no association between early ASM use and 18- or 24-month epilepsy risk in adults with new-onset TBI was of low quality. The analysis indicated a moderate quality for the evidence showing no effect on all-cause mortality. Therefore, higher-quality evidence is needed as a supplement for stronger recommendations.

Identifiers

PMID37066107
PMCPMC10101717
OpenAlexW4361250552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.