Evidence map›Paper›PMID 37066020›Full record

ArticleVirus evolution2023

Genomic epidemiology of human adenovirus F40 and F41 in coastal Kenya: A retrospective hospital-based surveillance study (2013-2022).

Arnold W Lambisia, Timothy O Makori, Martin Mutunga, Robinson Cheruiyot, Nickson Murunga, Joshua Quick, George Githinji, D James Nokes, Charlotte J Houldcroft, Charles N Agoti

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Arnold W LambisiaKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-5312-0960
Timothy O MakoriKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.ORCID https://orcid.org/0000-0003-4482-9729
Martin MutungaKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.
Robinson CheruiyotKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.
Nickson MurungaKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.
Joshua QuickInstitute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.
George GithinjiKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-9640-7371
D James NokesKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.ORCID https://orcid.org/0000-0001-5426-1984
Charlotte J HouldcroftDepartment of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.ORCID https://orcid.org/0000-0002-1833-5285
Charles N AgotiKenya Medical Research Institute-Wellcome Trust Research Programme, PO Box 230-80108, Kilifi, Kenya.ORCID https://orcid.org/0000-0002-2160-567X
Kenya Medical Research Institute · KEPwani University · KEUniversity of Birmingham · GBUniversity of Cambridge · GB

Funding

EPA EP-C-15-003Wellcome Trust
6 · The paper itself

Abstract

Human enteric adenovirus species F (HAdV-F) is a leading cause of childhood diarrhoeal deaths. The genomic analysis would be key to understanding transmission dynamics, potential drivers of disease severity, and vaccine development. However, currently, there are limited HAdV-F genomic data globally. Here, we sequenced and analysed HAdV-F from stool samples collected in coastal Kenya between 2013 and 2022. The samples were collected at Kilifi County Hospital in coastal Kenya from children <13 years of age who reported a history of three or more loose stools in the previous 24 hours. The genomes were analysed together with the data from the rest of the world by phylogenetic analysis and mutational profiling. Types and lineages were assigned based on phylogenetic clustering consistent with the previously described criteria and nomenclature. Participant clinical and demographic data were linked to genotypic data. Of ninety-one cases identified using real-time Polymerase Chain Reaction, eighty-eight near-complete genomes were assembled, and these were classified into HAdV-F40 (

Indexed as

F40/41human adenovirus FKenyarecombination

Identifiers

PMID37066020
PMCPMC10091489
OpenAlexW4360752230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.