Evidence map›Paper›PMID 37065968›Full record

ArticleFrontiers in medical technology2023

Proof-of-concept study of compartmentalized lung ventilation using system for asymmetric flow regulation (SAFR).

Igor Barjaktarevic, Glen Meyerowitz, Onike Williams, I Obi Emeruwa, Nir Hoftman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medical technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Igor BarjaktarevicDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles, CA, United States.
Glen MeyerowitzUCLA Biodesign, University of California Los Angeles, Los Angeles, California, CA, United States.
Onike WilliamsUCLA Biodesign, University of California Los Angeles, Los Angeles, California, CA, United States.
I Obi EmeruwaDivision of Pulmonary and Critical Care Medicine, University of California Los Angeles, CA, United States.
Nir HoftmanDepartment of Anesthesiology, University of California Los Angeles, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asymmetrical distribution of acute lung injury in mechanically ventilated patients can result in a heterogeneity of gas distribution between different regions, potentially worsening ventilation-perfusion matching. Furthermore, overdistension of healthier, more compliant lung regions can lead to barotrauma and limit the effect of increased PEEP on lung recruitment. We propose a System for Asymmetric Flow Regulation (SAFR) which, combined with a novel double lumen endobronchial tube (DLT) may offer individualized lung ventilation to the left and right lungs, better matching each lung's mechanics and pathophysiology. In this preclinical experimental model, the performance of SAFR on gas distribution in a two-lung simulation system was tested. Our results indicate that SAFR may be a technically feasible and potentially clinically useful although further research is warranted.

Indexed as

acute respiratory distress syndrome (ARDS)asymmetric lung injurycompartmentalized lung ventilationlung heterogeneitysystem for asymmetric flow regulation

Identifiers

PMID37065968
PMCPMC10101564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.