ArticleFrontiers in neuroscience2023
DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review.Frontiers in immunology · 2026Pooled it
- Trial
- Evaluation of the DTI-ALPS index in neuromyelitis optica spectrum disorder: a cross-sectional study of its correlation with disease duration and disability.Neuroradiology · 2026Article
- Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.Translational stroke research · 2026Article
- Mapping knowledge structure and emerging trends in non-invasive brain-computer interface for stroke rehabilitation.IBRO neuroscience reports · 2026Article
- The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026Review
- Glymphatic dysfunction: a unifying hypothesis for delirium.Nature reviews. Neurology · 2026Review
- Association Between Glymphatic Function and White Matter Microstructural Injury in Patients With Cushing's Disease.Brain and behavior · 2026Article
- Similar DTI-ALPS metrics in Parkinson's disease and essential tremor: a cross-sectional comparative analysis.Neuroradiology · 2026Article
- Exploring the relationship between lymphatic system damage and insulin resistance in T2DM based on vascular periadventitial tensor analysis and triglyceride-glucose index.BMC endocrine disorders · 2026Article
- Post-stroke glymphatic and meningeal lymphatic dysfunction: mechanisms, imaging evidence, and translational challenges.Frontiers in stroke · 2026Review
- Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.IBRO neuroscience reports · 2025Article
- Impaired glymphatic system for upper limb motor dysfunction in patients with acute ischemic stroke.Quantitative imaging in medicine and surgery · 2025Article
- Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) in Ischemic Stroke: A Systematic Review of Diagnostic and Prognostic Performance for Post-Stroke Cognitive Impairment.Diagnostics (Basel, Switzerland) · 2025Review
- Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery.Brain informatics · 2025Article
- Noninvasive assessment of glymphatic dysfunction and IDH mutation in glioma with DTI-ALPS and DTI metrics.Quantitative imaging in medicine and surgery · 2025Article
- Glymphatic dysfunction as a biomarker for post-stroke cognitive impairment.Scientific reports · 2025Article
- Neurologic symptoms as a hallmark of glymphatic alteration in recovered patients with COVID-19.BMC neurology · 2025Article
- Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.Science advances · 2025Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Brain glymphatic dysfunction is involved in the pathologic process of acute ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in subacute IS has not been fully elucidated. Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was used in this study to explore whether glymphatic activity was related to motor dysfunction in subacute IS patients. Methods: Twenty-six subacute IS patients with a single lesion in the left subcortical region and 32 healthy controls (HCs) were recruited in this study. The DTI-ALPS index and DTI metrics (fractional anisotropy, FA, and mean diffusivity, MD) were compared within and between groups. Spearman's and Pearson's partial correlation analyses were performed to analyze the relationships of the DTI-ALPS index with Fugl-Meyer assessment (FMA) scores and with corticospinal tract (CST) integrity in the IS group, respectively. Results: Six IS patients and two HCs were excluded. The left DTI-ALPS index of the IS group was significantly lower than that of the HC group ( Conclusions: Glymphatic dysfunction is involved in subacute IS. DTI-ALPS could be a potential magnetic resonance (MR) biomarker of motor dysfunction in subacute IS patients. These findings contribute to a better understanding of the pathophysiological mechanisms of IS and provide a new target for alternative treatments for IS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.