2-Octylcyclopentanone Inhibits Beta Lactam Resistant Diabetic Wound Pathogens.

Nur Amiera Syuhada Rozman, Tong Woei Yenn, Leong Chean Ring, Syarifah Ab Rashid, Tan Wen-Nee, Jun Wei Lim

Abstract read

In one paragraph

Article in Tropical life sciences research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Nur Amiera Syuhada RozmanUniversiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

Tong Woei YennUniversiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

Leong Chean RingUniversiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

Syarifah Ab RashidUniversiti Kuala Lumpur, Branch Campus Malaysian Institute of Chemical and Bioengineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia.

Tan Wen-NeeChemistry Section, School of Distance Education, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.

Jun Wei LimDepartment of Fundamental and Applied Sciences, Institute of Sustainable Building, Centre for Biofuel and Biochemical Research, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial infection is a frequent complication of diabetic foot ulcers, with up to 82% of ulcers being infected at the initial stage of diabetes. Furthermore, the emergence of beta lactam resistant pathogens managed to eliminate the use of beta lactam antibiotics as a chemotherapeutic alternative. This further increases the amputation and mortality rate. Hence, the aim of this study is to evaluate antimicrobial efficacy of a ketone derivative 2-octylcyclopentanone against diabetic wound pathogens. The inhibitory activity of the compound was determined using disc diffusion and broth microdilution assay. Generally, 2-octylcyclopentanone showed broad-spectrum antimicrobial activity, particularly against beta lactam resistant pathogens. The compound showed comparably better antimicrobial activity than all reference antibiotics, including chloramphenicol, streptomycin, ampicillin and penicillin. In addition, the same compound also inhibits a clinically isolated

Indexed as

2-OctylcyclopentanoneAktiviti AntimikrobialAntimicrobial ActivityBeta Lactam ResistanceDiabetic Foot UlcerDiabetic Wound InfectionJangkitan Luka DiabetesKetahanan Beta LaktamUlser Kaki Diabetes

Identifiers

PMID37065798

DOI10.21315/tlsr2023.34.1.15

PMCPMC10093773

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