ArticleFrontiers in endocrinology2023
Gender bias in fetal malformations: A cross-sectional study in Asian populations.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Urological Malformations Identify the High-Burden Phenotype Among Children Hospitalized for Presumed Urinary Tract Infection: A Retrospective Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- Mind the Litter: The Critical Role of Intralitter Variables in Reproductive and Developmental Toxicology Research.Birth defects research · 2026Review
- Article
- Prevalence of Congenital Anomalies and Predictive Factors in Pregnant Women in Bahrain: A Retrospective Analysis.Life (Basel, Switzerland) · 2025Article
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3 authors.
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Abstract
Objectives: The aim of this study was to detect any gender bias in fetal malformation cases. Design: This study was a cross-sectional, quantitative survey. Subjects: Overall, 1,661 Asian fetal malformation cases involving induced abortions in the obstetrics department of the first Affiliated Hospital of Zhengzhou University from 2012 to 2021 were included. Main outcome measures: Measurements of ultrasound detectable structural malformations were classified into 13 subtypes. Karyotyping, single nucleotide polymorphism (SNP) array, or sequencing diagnosis of these fetus was also included in the outcome measures. Results: The sex ratio (male/female) of all malformation types was 1.446. Cardiopulmonary had the highest proportion of all malformation types with 28%. Diaphragmatic hernia, omphalocele, gastroschisis, nuchal translucency (NT), and Multy malformations had significantly higher proportions of males ( Conclusion: Sex differences are common with fetal malformations, with higher proportions of males. Genetic testing has been proposed to account for these differences.
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