Evidence map›Paper›PMID 37065428›Full record

ArticleSovremennye tekhnologii v meditsine2022

A Complex of Pyrosequencing-Based Methods for Detection of Somatic Mutations in Codons 600 and 601 of the

O P Dribnokhodova, A S Esman, V I Korchagin, A Yu Bukharina, E A Dunaeva, G V Leshkina, E V Borisova, Ya A Voiciehovskaya, A I Daoud, V N Khlyavich and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Pyrosequencing-Based Method forDiagnostics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

O P DribnokhodovaSenior Researcher, Scientific Group for Development of New Methods of Genetic Polymorphisms Detection; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
A S EsmanResearcher, Scientific Group for Development of New Methods of Genetic Polymorphisms Detections; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
V I KorchaginResearcher, Scientific Group for Development of New Methods of Genetic Polymorphisms Detections; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
A Yu BukharinaJunior Researcher, Scientific Group for Genomics and Post-genome Technology; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
E A DunaevaResearcher, Scientific Group for Development of New Methods of Genetic Polymorphisms Detections; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
G V LeshkinaBiologist, Molecular Diagnostic Methods Department; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
E V BorisovaPhysician, Clinical Diagnostic Laboratory; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
Ya A VoiciehovskayaResearcher, Scientific Group of Genetic Engineering and Biotechnology; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
A I DaoudHead of Clinical Diagnostic Laboratory; Foreign Unitary Consultancy Enterprise MedArt, 1B Platonov St., Minsk, 220034, Republic of Belarus.
V N KhlyavichUltrasound Diagnostic Physician, Oncologist; Foreign Unitary Consultancy Enterprise MedArt, 1B Platonov St., Minsk, 220034, Republic of Belarus.
K O MironovHead of Scientific Group for Development of New Methods of Genetic Polymorphisms Detection; Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 3A Novogireevskaya St., Moscow, 111123, Russia.
Fondation Jean Dausset-CEPH · FRCentral Research Institute of Epidemiology · RUFederal Service for Surveillance on Consumer Rights Protection and Human Wellbeing · RUGenomics (United Kingdom) · GBMoscow Clinical Scientific Center · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: The nucleotide sequence of the Results: The developed methods allow to determine 2% of the V600E or V600M mutations, 1% of the V600K and V600R mutations, and 3% of the K601E mutations in samples with high DNA concentration; it is also possible to confidently detect at least 5% of the mutant allele for all mutations in low concentration samples (less than 500 copies/PCR). During biological material testing, 53 samples with the V600E mutation were detected; the proportion of the mutant allele was 4.9-50.0%. Conclusion: A complex of methods for determination of the nucleotide sequence of the

Indexed as

Proto-Oncogene Proteins B-rafThyroid NoduleCodonHigh-Throughput Nucleotide SequencingHumansMutationBRAF protein, humanCodonProto-Oncogene Proteins B-rafBRAFfine-needle aspiration biopsyoncogeneticspyrosequencingthyroid cancer

Identifiers

PMID37065428
PMCPMC10090924
OpenAlexW4225156101

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.