ReviewInterface focus2023
Neuromodulatory control of complex adaptive dynamics in the brain.
Review in Interface focus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- Dynamic salience as a basis for behavioural meta-malleability.Royal Society open science · 2026Review
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Rebalancing α-Synuclein Clearance: Novel Therapeutic Frontiers in Parkinson's Disease.Neuromolecular medicine · 2026Review
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Lineage-specific decoupling of arginine vasotocin-evoked aggression in male darters (Percidae: Etheostomatinae).Hormones and behavior · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical whole-brain modeling of critical synchronization dynamics in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Emergent flow theory: autonomic coherence as a gain parameter for the temporal architecture of conscious integration.Frontiers in integrative neuroscience · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Impact of visual preferences for indoor green walls on emotion and brain activity of college students.Scientific reports · 2025Article
- The neuroreceptors and transporters underlying spontaneous brain activity.Communications biology · 2025Article
- Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Context-Sensitive Conscious Interpretation and Layer-5 Pyramidal Neurons in Multistable Perception.Brain and behavior · 2025Review
- Beyond Mechanism-Extending Our Concepts of Causation in Neuroscience.The European journal of neuroscience · 2025Review
- Topographic Axes of Wiring Space Converge to Genetic Topography in Shaping the Human Cortical Layout.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dopamine alters functional gradients in Parkinson's disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks.iScience · 2024Article
- Associative memory in alcohol-related contexts: An fMRI study with young binge drinkers.Journal of psychopharmacology (Oxford, England) · 2024Article
- Adaptive fuzzy iterative learning control based neurostimulation system and in-silico evaluation.Cognitive neurodynamics · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How is the massive dimensionality and complexity of the microscopic constituents of the nervous system brought under sufficiently tight control so as to coordinate adaptive behaviour? A powerful means for striking this balance is to poise neurons close to the critical point of a phase transition, at which a small change in neuronal excitability can manifest a nonlinear augmentation in neuronal activity. How the brain could mediate this critical transition is a key open question in neuroscience. Here, I propose that the different arms of the ascending arousal system provide the brain with a diverse set of heterogeneous control parameters that can be used to modulate the excitability and receptivity of target neurons-in other words, to act as control parameters for mediating critical neuronal order. Through a series of worked examples, I demonstrate how the neuromodulatory arousal system can interact with the inherent topological complexity of neuronal subsystems in the brain to mediate complex adaptive behaviour.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.