ArticleInterface focus2023
The lack of temporal brain dynamics asymmetry as a signature of impaired consciousness states.
Article in Interface focus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.medRxiv : the preprint server for health sciences · 2025Article
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Large-scale cortical functional networks are organized in structured cycles.Nature neuroscience · 2025Article
- Dynamics of EEG Microstates Change Across the Spectrum of Disorders of Consciousness.Brain topography · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.PLoS computational biology · 2025Article
- Multilevel irreversibility reveals higher-order organization of nonequilibrium interactions in human brain dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Understanding Altered Dynamics in Cocaine Use Disorder Through State Transitions Mediated by Artificial Perturbations.Brain sciences · 2025Article
- Navigating Pubertal Goldilocks: The Optimal Pace for Hierarchical Brain Organization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in in vitro cortical neural circuits.Network neuroscience (Cambridge, Mass.) · 2024Article
- Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex.PLoS computational biology · 2024Article
- Analyzing asymmetry in brain hierarchies with a linear state-space model of resting-state fMRI data.Network neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life is a constant battle against equilibrium. From the cellular level to the macroscopic scale, living organisms as dissipative systems require the violation of their detailed balance, i.e. metabolic enzymatic reactions, in order to survive. We present a framework based on temporal asymmetry as a measure of non-equilibrium. By means of statistical physics, it was discovered that temporal asymmetries establish an arrow of time useful for assessing the reversibility in human brain time series. Previous studies in human and non-human primates have shown that decreased consciousness states such as sleep and anaesthesia result in brain dynamics closer to the equilibrium. Furthermore, there is growing interest in the analysis of brain symmetry based on neuroimaging recordings and since it is a non-invasive technique, it can be extended to different brain imaging modalities and applied at different temporo-spatial scales. In the present study, we provide a detailed description of our methodological approach, paying special attention to the theories that motivated this work. We test, for the first time, the reversibility analysis in human functional magnetic resonance imaging data in patients suffering from disorder of consciousness. We verify that the tendency of a decrease in the asymmetry of the brain signal together with the decrease in non-stationarity are key characteristics of impaired consciousness states. We expect that this work will open the way for assessing biomarkers for patients' improvement and classification, as well as motivating further research on the mechanistic understanding underlying states of impaired consciousness.
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