ArticleFrontiers in cellular and infection microbiology2023
Maternal vaginal microbiome composition does not affect development of the infant gut microbiome in early life.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Mother-to-infant vertical transmission in early life: a systematic review and proportional meta-analysis of Bifidobacterium strain transmissibility.NPJ biofilms and microbiomes · 2025Pooled it
- Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategies.Microbiome · 2024Pooled it
- Maternal-to-neonatal microbial transmission and impact of prenatal probiotics on neonatal gut development.Journal of translational medicine · 2025Trial
- Antibiotic-Driven Gut Microbiome Dysbiosis: Resistome Dynamics, Metabolic Disruption, and Paths to Restoration.Antibiotics (Basel, Switzerland) · 2026Review
- The maternal-infant microbiome axis as an epigenetic and immunometabolic orchestrator: redefining early-life programming and precision interventions for lifelong women's and children's health.Infection and immunity · 2026Review
- Impact of maternal fecal microbiota on the early development of neonatal gut microbial community.Frontiers in pediatrics · 2026Article
- Exploring the role of the gut microbiome in pediatric gastrointestinal and neurological health.Translational pediatrics · 2025Review
- Microbiological Foundations to Optimise Intrinsic Capacity and Promote Healthy Ageing: An Integration Into the Life Course Approach.Aging cell · 2025Review
- Transformation ofMicrobiology spectrum · 2025Article
- Maternal vaginal and fecal microbiota in later pregnancy contribute to child fecal microbiota development in the ECHO cohort.iScience · 2025Article
- Influence of gut microbiota on the pediatric endocrine system and associated disorders.Annals of medicine and surgery (2012) · 2025Review
- Potential postmortem microbial biomarkers of infant and younger children death investigation.Journal of forensic sciences · 2025Article
- Maternal gut microbiota and placenta-derived tissues microbes are important for initial gut microbial colonization in infants.Frontiers in microbiology · 2025Article
- The early-life gut microbiome in common pediatric diseases: roles and therapeutic implications.Frontiers in nutrition · 2025Review
- Intestinal dysbiosis during pregnancy and microbiota-associated impairments in offspring.Frontiers in microbiomes · 2025Review
- The Influence of Premature Birth on the Development of Pulmonary Diseases: Focus on the Microbiome.Metabolites · 2024Review
- Delivery mode is a larger determinant of infant gut microbiome composition at 6 weeks than exposure to peripartum antibiotics.Microbial genomics · 2024Article
- Birth Mode Does Not Determine the Presence of Shared Bacterial Strains between the Maternal Vaginal Microbiome and the Infant Stool Microbiome.Microbiology spectrum · 2023Article
- Factors affecting the early establishment of neonatal intestinal flora and its intervention measures.Frontiers in cellular and infection microbiology · 2023Review
- Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet.Frontiers in microbiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 1 country.
Funding
Abstract
Birth mode has been implicated as a major factor influencing neonatal gut microbiome development, and it has been assumed that lack of exposure to the maternal vaginal microbiome is responsible for gut dysbiosis among caesarean-delivered infants. Consequently, practices to correct dysbiotic gut microbiomes, such as vaginal seeding, have arisen while the effect of the maternal vaginal microbiome on that of the infant gut remains unknown. We conducted a longitudinal, prospective cohort study of 621 Canadian pregnant women and their newborn infants and collected pre-delivery maternal vaginal swabs and infant stool samples at 10-days and 3-months of life. Using
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.