ArticleACS catalysis2022
Zinc-Free, Scalable Reductive Cross-Electrophile Coupling Driven by Electrochemistry in an Undivided Cell.
Article in ACS catalysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- Development of Kilogram-Scale Electrochemical Ni-Catalyzed Cross Electrophile Coupling in Flow.Organic process research & development · 2026Article
- Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes.Nature chemistry · 2026Article
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Homogeneous catalysis in continuous flow integrating photocatalysis, electrocatalysis, and automation technologies.Communications chemistry · 2025Review
- Use of Electron-Transfer Mediators to Access Higher Electrochemical Current Densities in Ni-Catalyzed Cross-Electrophile Coupling.Journal of the American Chemical Society · 2025Article
- Borohydride Oxidation as Counter Reaction in Reductive Electrosynthesis.Angewandte Chemie (International ed. in English) · 2025Article
- Translation of Nickel-Catalyzed C(spOrganic letters · 2025Article
- Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport.ACS central science · 2025Article
- Development status of electrocatalytic hydrogenation of biomass small molecules and prospects for industrial production.iScience · 2025Review
- Ni-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions.Journal of the American Chemical Society · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- The Future of Electro-organic Synthesis in Drug Discovery and Early Development.ACS organic & inorganic Au · 2024Review
- Zinc and manganese redox potentials in organic solvents and their influence on nickel-catalysed cross-electrophile coupling.Nature chemistry · 2024Article
- Non-Innocent Role of Sacrificial Anodes in Electrochemical Nickel-Catalyzed C(spJournal of the American Chemical Society · 2024Article
- Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides.The Journal of organic chemistry · 2024Article
- Paired Electrolysis Enables Reductive Heck Coupling of Unactivated (Hetero)Aryl Halides and Alkenes.Angewandte Chemie (International ed. in English) · 2024Article
- Nickel-Catalyzed Electrochemical Cross-Electrophile C(spAngewandte Chemie (International ed. in English) · 2024Article
- Sacrificial Anode-Free Electrochemical Cross-Electrophile Coupling of 1,3-Diol Derivatives to Form Aliphatic and Aryl Cyclopropanes.Organic letters · 2024Article
- Bis(pinacolato)diboron-Enabled Ni-Catalyzed Reductive Arylation/Vinylation of Alkyl Electrophiles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bromide-Mediated Silane Oxidation: A Practical Counter-Electrode Process for Nonaqueous Deep Reductive Electrosynthesis.JACS Au · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Nickel-catalyzed reductive cross-electrophile coupling reactions are becoming increasingly important in organic synthesis, but application at scale is limited by three interconnected challenges: a reliance on amide solvents (complicated workup, regulated), the generation of stoichiometric Zn salts (complicated isolation, waste disposal issue), and mixing/activation challenges of zinc powder. We show here an electrochemical approach that addresses these three issues: the reaction works in acetonitrile with diisopropylethylamine as the terminal reductant in a simple undivided cell (graphite(+)/nickel foam(-)). The reaction utilizes a combination of two ligands, 4,4'-di-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.