ReviewFrontiers in microbiology2023
Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications.
Review in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Carotenoids of Halophilic Archaea: Production, Properties and Biotechnological Applications.Probiotics and antimicrobial proteins · 2026Review
- Uncovering transcriptional processes in microbial communities adapted to differing saline conditions in salt-weathered historic buildings.Microbiome · 2026Article
- Review
- A New Era for Using Natural Pigments: The Case of the CBiotechnology and applied biochemistry · 2026Review
- Recent Advances in Understanding Bio-Compounds from Haloarchaea.Journal of microbiology and biotechnology · 2026Review
- Airborne Halophilic and Non-Halophilic Microbial Communities in an Underground Salt Mine Affected by Seasonal Environmental Fluctuations.Environmental microbiology reports · 2026Article
- Characterization and Functional Evaluation of Carotenoids From Haloarcula rubripromontorii BS2.MicrobiologyOpen · 2026Article
- Identification and Cultivation of Biotechnologically Relevant Microalgal and Cyanobacterial Species Isolated from Sečovlje Salt Pans, Slovenia.Marine drugs · 2026Article
- Rock surfaces as reservoirs for airborne halophilic microorganisms in the Bochnia Salt Mine.Frontiers in microbiology · 2026Article
- Editorial: Extremophiles in biotechnology: challenges and advancements in sustainable applications.Frontiers in microbiology · 2026Article
- Biotechnological Applications of Archaea.Progress in molecular and subcellular biology · 2026Review
- Hydrostatic pressure-enabled transformation inFrontiers in microbiology · 2026Article
- Bacterioruberin (CNutrients · 2025Review
- Enhancing the in vitro anticancer efficacy of Paclitaxel against triple-negative breast cancer via an exopolysaccharide from a haloalkaliphilic archaeal strain.Scientific reports · 2025Article
- Review
- Carotenoids in Skin Photoaging: Unveiling Protective Effects, Molecular Insights, and Safety and Bioavailability Frontiers.Antioxidants (Basel, Switzerland) · 2025Review
- Advanced Strategies for Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production: PHA Synthase Homologous Overexpression in the ExtremophileMarine drugs · 2025Article
- Strategies of Environmental Adaptation in the Haloarchaeal GeneraMicroorganisms · 2025Article
- Comparative genomics of the highly halophilic Haloferacaceae.Scientific reports · 2024Article
- Genome-based classification of Halobellus rubicundus sp. nov., a novel extremely halophilic archaeon isolated from a Korean solar saltern.Extremophiles : life under extreme conditions · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine environments and salty inland ecosystems encompass various environmental conditions, such as extremes of temperature, salinity, pH, pressure, altitude, dry conditions, and nutrient scarcity. The extremely halophilic archaea (also called haloarchaea) are a group of microorganisms requiring high salt concentrations (2-6 M NaCl) for optimal growth. Haloarchaea have different metabolic adaptations to withstand these extreme conditions. Among the adaptations, several vesicles, granules, primary and secondary metabolites are produced that are highly significant in biotechnology, such as carotenoids, halocins, enzymes, and granules of polyhydroxyalkanoates (PHAs). Among halophilic enzymes, reductases play a significant role in the textile industry and the degradation of hydrocarbon compounds. Enzymes like dehydrogenases, glycosyl hydrolases, lipases, esterases, and proteases can also be used in several industrial procedures. More recently, several studies stated that carotenoids, gas vacuoles, and liposomes produced by haloarchaea have specific applications in medicine and pharmacy. Additionally, the production of biodegradable and biocompatible polymers by haloarchaea to store carbon makes them potent candidates to be used as cell factories in the industrial production of bioplastics. Furthermore, some haloarchaeal species can synthesize nanoparticles during heavy metal detoxification, thus shedding light on a new approach to producing nanoparticles on a large scale. Recent studies also highlight that exopolysaccharides from haloarchaea can bind the SARS-CoV-2 spike protein. This review explores the potential of haloarchaea in the industry and biotechnology as cellular factories to upscale the production of diverse bioactive compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.