Evidence map›Paper›PMID 37065143›Full record

ArticleFrontiers in microbiology2023

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease.

Vardan Tsaturyan, Anahit Manvelyan, Marine Balayan, Natalya Harutyunyan, Elya Pepoyan, Tamas Torok, Michael Chikindas, Astghik Pepoyan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Placebo-resistant gut bacteria:Frontiers in cellular and infection microbiology · 2024
    Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. GutWomen's health reports (New Rochelle, N.Y.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Vardan TsaturyanFaculty of Military Medicine, Yerevan State Medical University, Yerevan, Armenia.
Anahit ManvelyanInternational Association for Human and Animals Health Improvement, Yerevan, Armenia.
Marine BalayanInternational Association for Human and Animals Health Improvement, Yerevan, Armenia.
Natalya HarutyunyanInternational Association for Human and Animals Health Improvement, Yerevan, Armenia.
Elya PepoyanInternational Association for Human and Animals Health Improvement, Yerevan, Armenia.
Tamas TorokEarth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
Michael ChikindasHealth Promoting Naturals Laboratory, Rutgers State University, New Brunswick, NJ, United States.
Astghik PepoyanInternational Association for Human and Animals Health Improvement, Yerevan, Armenia.
Armenian National Agrarian University · AMLawrence Berkeley National Laboratory · USNational Academy of Sciences of Armenia · AMRutgers, The State University of New Jersey · USYerevan State Medical University · AM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19. Objective: Current investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the course of COVID-19 severity? ii. How does the COVID-19 disease course on go for FMF patients who have been taking colchicine as a medication over the years after getting infected with SARS-CoV-2? iii. Is there an initial gut micribiota structure pattern for non-FMF and FMF patients in the cases when COVID-19 appears in mild form? Methods: The gut microbiota composition in non-FMF and FMF patients before the first infection (mild and moderate course of COVID-19) was considered. COVID-19 was diagnosed by SARS-CoV-2 nucleic acid RT-PCR in nasopharyngeal swab and/or sputum. Results: The number of patients with male FMF with mild COVID-19 was approximately two times higher than that of non-FMF male subjects with COVID-19. In addition, an association of COVID-19 disease severity with the baseline gut

Indexed as

COVID-19disease severity analysisfamilial Mediterranean fever diseasegendergut microbiota

Identifiers

PMID37065143
PMCPMC10098164
OpenAlexW4361273102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.