Evidence map›Paper›PMID 37065091›Full record

ArticleBrain communications2023

Cervical spinal cord injury leads to injury and altered metabolism in the lungs.

Emily E Huffman, Brittany E Dong, Harrison A Clarke, Lyndsay E A Young, Matthew S Gentry, Derek B Allison, Ramon C Sun, Christopher M Waters, Warren J Alilain

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emily E HuffmanDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID https://orcid.org/0000-0002-8766-2319
Brittany E DongDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40508, USA.
Harrison A ClarkeDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40508, USA.
Lyndsay E A YoungMarkey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.
Matthew S GentryMarkey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.
Derek B AllisonMarkey Cancer Center, University of Kentucky, Lexington, KY 40508, USA.
Ramon C SunDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40508, USA.ORCID https://orcid.org/0000-0002-3009-1850
Christopher M WatersDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY 40508, USA.
Warren J AlilainDepartment of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40508, USA.
University of Kentucky · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2012 to 2017
$13.7M
Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
Brain Glycogen-Metabolism,Mechanisms, and Therapeutic PotentialR35NS116824 · NINDS · UNIVERSITY OF KENTUCKY · PI Matthew S. Gentry · 2020 to 2026
$8.2M
Biophysical Mechanisms of Hyperoxia-Induced Lung InjuryR01HL151419 · NHLBI · UNIVERSITY OF KENTUCKY · PI WATERS, CHRISTOPHER M · 2020 to 2023
$2.1M
Aberrant Glycogen Modulates Cerebral Glucose Metabolism in Aging and Alzheimer's DiseaseR01AG066653 · NIA · UNIVERSITY OF KENTUCKY · PI SUN, RAMON C. · 2020 to 2024
$1.9M
ASK1 and Ventilator-Induced Lung InjuryR01HL131526 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WATERS, CHRISTOPHER M · 2017 to 2020
$1.7M
Promoting and understanding recovery of breathing after chronic spinal cord injuryR01NS101105 · NINDS · UNIVERSITY OF KENTUCKY · PI ALILAIN, WARREN JOSEPH · 2017 to 2021
$1.7M
Investigating Lung Injury After Cervical Spinal Cord InjuryR21NS121966 · NINDS · UNIVERSITY OF KENTUCKY · PI ALILAIN, WARREN JOSEPH · 2021 to 2021
$421k
NCATS NIH HHS UL1 TR001998NHLBI NIH HHS R01 HL131526NHLBI NIH HHS R01 HL151419NIA NIH HHS R01 AG066653NIGMS NIH HHS P20 GM103527NINDS NIH HHS P01 NS097197NINDS NIH HHS R01 NS101105NINDS NIH HHS R21 NS121966NINDS NIH HHS R35 NS116824
6 · The paper itself

Abstract

High-cervical spinal cord injury often disrupts respiratory motor pathways and disables breathing in the affected population. Moreover, cervically injured individuals are at risk for developing acute lung injury, which predicts substantial mortality rates. While the correlation between acute lung injury and spinal cord injury has been found in the clinical setting, the field lacks an animal model to interrogate the fundamental biology of this relationship. To begin to address this gap in knowledge, we performed an experimental cervical spinal cord injury

Indexed as

lung injurymetabolismspinal cord injury

Identifiers

PMID37065091
PMCPMC10090796
OpenAlexW4361204547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.