Evidence map›Paper›PMID 37064920›Full record

ReviewFrontiers in physiology2023

Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms.

Ashtin G Beckett, Mia D McFadden, Junie P Warrington

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Pregnancy hypertension is associated with higher p-tau217 in healthy midlife women.The journal of prevention of Alzheimer's disease · 2025
    Article
  9. Article
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  11. Review
  12. Reduced ATHypertension (Dallas, Tex. : 1979) · 2025
    Article
  13. Article
  14. Review
  15. Pregnancy-induced oxidative stress and inflammation are not associated with impaired maternal neuronal activity or memory function.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashtin G BeckettDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, United States.
Mia D McFaddenSchool of Medicine, University of Mississippi Medical Center, Jackson, MS, United States.
Junie P WarringtonDepartment of Neurology, University of Mississippi Medical Center, Jackson, MS, United States.

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy such as preeclampsia, eclampsia, superimposed preeclampsia, and gestational hypertension are major causes of fetal and maternal morbidity and mortality. Women with a history of hypertensive pregnancy disorders have increased risk of stroke and cognitive impairments later in life. Moreover, women with a history of preeclampsia have increased risk of mortality from diseases including stroke, Alzheimer's disease, and cardiovascular disease. The underlying pathophysiological mechanisms are currently not fully known. Here, we present clinical, epidemiological, and preclinical studies focused on evaluating the long-term cerebrovascular and cognitive dysfunction that affect women with a history of hypertensive pregnancy disorders and discuss potential underlying pathophysiological mechanisms.

Indexed as

Alzheimer’s diseaseblood-brain barrierpostpartumpreeclampsiastrokevascular dementiawhite matter lesions

Identifiers

PMID37064920
PMCPMC10102351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.