Evidence map›Paper›PMID 37064832›Full record

ArticleClinical and experimental hepatology2023

Genetic profile of MIF single nucleotide polymorphism (rs755622 G>C) in hepatocellular carcinoma among Egyptian patients.

Heba Ahmed Osman, Marwa El-Sayed, Mohammed Tag-Adeen, Ahlam Sabra, Samer A El-Sawy, Marwa Ahmed Mahmoud, Saeda Mohamed Abd Elwahab, Mohammed Wahman, Mohammed H Hassan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Heba Ahmed OsmanDepartment of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Marwa El-SayedDepartment of Medical Microbiology and Immunology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Mohammed Tag-AdeenDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Ahlam SabraDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Samer A El-SawyDepartment of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
Marwa Ahmed MahmoudDepartment of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Saeda Mohamed Abd ElwahabDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, South Valley University, Qena, Egypt.
Mohammed WahmanDepartment of Oncology and Nuclear Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.
Mohammed H HassanDepartment of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, Egypt.
South Valley University · EGSohag University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim of the study: To evaluate the role of MIF gene polymorphism rs755622 G>C in occurrence and progression of hepatocellular carcinoma (HCC) among a cohort of Egyptian patients. Material and methods: This case-control study was conducted on 50 patients with HCC after chronic viral hepatitis and 50 healthy volunteers, recruited between July 2021 and January 2022. All patients with HCC were evaluated for severity of liver disease using a Child-Pugh score, and TNM and BCLC scoring systems. MIF 173 G>C (rs755622) single nucleotide polymorphism was performed for all participants by polymerase chain reaction using restriction fragment length polymorphism technique (RFLP-PCR). Results: Overall results showed significantly higher frequencies of GG (wild homozygous genotype) and mutant heterozygous genotype GC and G allele (OR = 6.303, 95% CI: 3.374-11.775) among patients with HCC compared to the control group ( Conclusions: An obvious role of MIF (rs755622) gene polymorphism could have an important role in susceptibility and progression of HCC among patients with chronic viral hepatitis induced liver cirrhosis.

Indexed as

HBVHCCHCVMIFrs755622RFLP-PCR

Identifiers

PMID37064832
PMCPMC10090993
OpenAlexW4352998650

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.