Evidence map›Paper›PMID 37064810›Full record

ReviewSovremennye tekhnologii v meditsine2022

Decellularized Extracellular Matrix for Tissue Engineering (Review).

E V Isaeva, E E Beketov, N V Arguchinskaya, S А Ivanov, P V Shegay, А D Kaprin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Sovremennye tekhnologii v meditsine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

E V IsaevaSenior Researcher, Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia.
E E BeketovHead of the Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia.
N V ArguchinskayaJunior Researcher, Laboratory of Biomaterials and Tissue Constructions; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia.
S А IvanovDirector; A. Tsyb Меdical Radiological Research Centre - Branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, 10 Zhukova St., Obninsk, 249036, Russia; Professor, Department of Oncology and Radiology and Nuclear Medicine; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.
P V ShegayHead of the Center of Innovative Radiological and Regenerative Technologies; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia.
А D KaprinProfessor, Academician of the Russian Academy of Sciences, General Director; National Medical Research Radiological Center of the Ministry of Health of the Russian Federation, 4 Koroleva St., Obninsk, 249036, Russia Head of the Department of Urology and Operative Nephrology with the Course of Oncourology of the Medical Institute; Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, decellularized tissues have evolved into a new, full-fledged platform for the creation of tissue-engineered constructions. Extracellular matrix (ECM) of each tissue provides a unique tissue-specific microenvironment for resident cells with the structure and biochemical signaling required for their functioning. The decellularized ECM (dECM) has been established to influence cell differentiation. The review provides recent data on the composition and functions of the ECM, methods for obtaining decellularized tissues, and their application in tissue engineering depending on their physical form (scaffold, powder, or hydrogel). The effect of the matrix source, decellularization and sterilization techniques on dECM composition has been considered. Regulatory mechanisms of cell differentiation by the extracellular matrix are discussed. Differences in the protein composition of the native and decellularized materials are presented. Application of dECM in the bioink composition for regeneration of various tissues using bioprinting technologies is also considered. It has been concluded that successful application of dECM in tissue engineering and regenerative medicine requires a permanent and biologically suitable dECM source, optimized tissue decellularization protocols, improved mechanical properties of dECM-derived bioinks, and prevention of immunological reaction of the organism.

Indexed as

Decellularized Extracellular MatrixTissue EngineeringExtracellular MatrixHydrogelsRegenerative MedicineDecellularized Extracellular MatrixHydrogelsdecellularizationdecellularized extracellular matrixdECMextracellular matrix remodelingtissue engineering

Identifiers

PMID37064810
PMCPMC10090917

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.