ArticleFrontiers in public health2023
Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 11 citations in OpenAlex.
- Lipid-Based Nanocarriers as a Promising Delivery System in the Management of Acne.Current pharmaceutical design · 2026Review
- Multidimensional assessment of acne vulgaris: links between psychiatric symptoms, disordered eating, and dermatologic severity.Frontiers in medicine · 2026Article
- A Multi-Omics Study of Comorbid Mechanisms Between Depression and Inflammatory Dermatoses Identifies FADS1 and TMEM258 as Therapeutic Targets.Clinical, cosmetic and investigational dermatology · 2026Article
- The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study.Cell biochemistry and biophysics · 2025Article
- Self-esteem, self-perception, and self-image of women with acne vulgaris at different age ranges.Dermatology reports · 2025Article
- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- An In Vitro Study of the Anti-Acne Effects ofMolecules (Basel, Switzerland) · 2025Article
- Investigating the Impact of Circulating Immune Cells on Acne Using Mendelian Randomization.Clinical, cosmetic and investigational dermatology · 2025Article
- Unraveling the Causal Relationship Between Blood Metabolites and Acne: A Metabolomic Mendelian Randomization Study.Journal of cosmetic dermatology · 2025Article
- Body image and mental health challenges in adolescents with acne.Postepy dermatologii i alergologii · 2025Article
- Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization.Frontiers in psychiatry · 2024Article
- A Mendelian randomization analysis of inflammatory skin disease risk due to mineral deficiencies.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies. Methods: We performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne ( Results: There was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, Conclusion: The increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented.
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